2-(4-chloro-benzoylamino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid

Base Information

• Chemical Name: 2-(4-chloro-benzoylamino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid
• CAS No.: 52535-76-9
• Molecular Formula: C₁₆H₁₄ClNO₃S
• Molecular Weight: 335.811

Synonyms:2-(4-chloro-benzoylamino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid

Chemical Property of 2-(4-chloro-benzoylamino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid

Chemical Property:

• Boiling Point: 453.3±45.0 °C(Predicted)
• Density: 1.465±0.06 g/cm3(Predicted)

Purity/Quality:

MsbAinhibitor1 >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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Technology Process of 2-(4-chloro-benzoylamino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid

There total 5 articles about 2-(4-chloro-benzoylamino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-chloro)benzamide-6-ethyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid ethyl ester (52535-71-4) → 2-(4-chloro-benzoylamino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid (52535-76-9)

Guidance literature:

With sodium hydroxide; In methanol;

DOI:10.1007/BF00477559

Reference yield:

ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (4506-71-2) → 2-(4-chloro-benzoylamino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid (52535-76-9)

Guidance literature:

Multi-step reaction with 2 steps

2: aq. NaOH / methanol

With sodium hydroxide; In methanol;

DOI:10.1007/BF00477559

Reference yield:

4-chloro-benzoyl chloride (122-01-0) → 2-(4-chloro-benzoylamino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid (52535-76-9)

Guidance literature:

Multi-step reaction with 2 steps

2: aq. NaOH / methanol

With sodium hydroxide; In methanol;

DOI:10.1007/BF00477559

upstream raw materials:

2-(4-chloro)benzamide-6-ethyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid ethyl ester

ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

4-chloro-benzoyl chloride

para-chlorobenzoic acid

Downstream raw materials:

4-chloro-N-(4,5,6,7-tetrahydro-benzo[b]thiophen-2-yl)-benzamide

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