7-(4-(3-cyclopentenylbenzyl)piperazin-1-yl)-3,4-dihydroquinazolin-2(1H)-one

Base Information

Chemical Name:7-(4-(3-cyclopentenylbenzyl)piperazin-1-yl)-3,4-dihydroquinazolin-2(1H)-one
CAS No.:1630951-35-7
Molecular Formula:C₂₄H₂₈N₄O
Molecular Weight:388.513
Hs Code.:

Synonyms:7-(4-(3-cyclopentenylbenzyl)piperazin-1-yl)-3,4-dihydroquinazolin-2(1H)-one

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Chemical Property of 7-(4-(3-cyclopentenylbenzyl)piperazin-1-yl)-3,4-dihydroquinazolin-2(1H)-one

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Technology Process of 7-(4-(3-cyclopentenylbenzyl)piperazin-1-yl)-3,4-dihydroquinazolin-2(1H)-one

There total 12 articles about 7-(4-(3-cyclopentenylbenzyl)piperazin-1-yl)-3,4-dihydroquinazolin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 680203-54-7
3-cyclopenten-1-yl-benzaldehyde

: 1630951-23-3
7-(piperazin-1-yl)-3,4-dihydroquinazolin-2(1H)-one trifluoroacetate

: 1630951-35-7
7-(4-(3-cyclopentenylbenzyl)piperazin-1-yl)-3,4-dihydroquinazolin-2(1H)-one

Guidance literature:: 3-cyclopenten-1-yl-benzaldehyde; 7-(piperazin-1-yl)-3,4-dihydroquinazolin-2(1H)-one trifluoroacetate; With triethylamine; In dimethyl sulfoxide; at 0 - 20 ℃; for 0.5h;

With sodium triacetoxy borohydride; In dimethyl sulfoxide; for 6h;
DOI:10.2174/15734064113096660046

Reference yield: 65.0%

: 1630951-35-7
7-(4-(3-cyclopentenylbenzyl)piperazin-1-yl)-3,4-dihydroquinazolin-2(1H)-one

Guidance literature:: With triethylamine; In dimethyl sulfoxide; at 0 - 20 ℃; for 0.5h;

With sodium tris(acetoxy)borohydride; In dimethyl sulfoxide; at 20 ℃; for 6h;

Reference yield:

: 591-19-5
m-Bromoaniline

: 1630951-35-7
7-(4-(3-cyclopentenylbenzyl)piperazin-1-yl)-3,4-dihydroquinazolin-2(1H)-one

Guidance literature:: Multi-step reaction with 11 steps

1.1: hydroxylamine hydrochloride; sodium sulfate

2.1: sulfuric acid / 0.5 h / 60 °C

3.1: hydroxylamine hydrochloride / water; ethanol / 12 h

4.1: 2,6-dimethylpyridine; trifluoromethylsulfonic anhydride / dichloromethane / 3 h / 0 °C / Cooling with ice; Reflux

4.2: 1 h / 20 - 30 °C

5.1: trifluoroacetic acid / 0.17 h / 0 °C / Cooling with ice

5.2: 2.5 h / 0 - 50 °C

6.1: triethylamine / N,N-dimethyl-formamide / 6 h / 70 °C

7.1: hydrogen / ethanol; tetrahydrofuran / 12 h / 3102.97 Torr

8.1: potassium hydroxide / water; ethanol / 12 h / 20 - 90 °C

9.1: tetrahydrofuran / 6 h / 20 - 80 °C

10.1: dichloromethane; tetrahydrofuran / 6 h / 0 - 20 °C

11.1: triethylamine / dimethyl sulfoxide / 0.5 h / 0 - 20 °C

11.2: 6 h

With 2,6-dimethylpyridine; trifluoromethylsulfonic anhydride; sulfuric acid; hydroxylamine hydrochloride; hydrogen; sodium sulfate; triethylamine; trifluoroacetic acid; potassium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.2174/15734064113096660046