TRI-ACETYL PYRIDOXINE

Base Information

• Chemical Name: TRI-ACETYL PYRIDOXINE
• CAS No.: 10030-93-0
• Molecular Formula: C14H17 N O6
• Molecular Weight: 295.292
• Hs Code.: 2933399090
• Mol file: 10030-93-0.mol

Synonyms:3,4-Pyridinedimethanol,5-(acetyloxy)-6-methyl-, diacetate (ester) (9CI); Pyridoxol, triacetate (7CI);Pyridoxol, triacetate (ester) (8CI); Pyridoxine triacetate; Pyridoxol acetate

Chemical Property of TRI-ACETYL PYRIDOXINE

Chemical Property:

• PSA: 91.79000
• LogP: 1.44150

Purity/Quality:

98%,99%, ^*data from raw suppliers

TRI-ACETYL PYRIDOXINE 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TRI-ACETYL PYRIDOXINE

There total 4 articles about TRI-ACETYL PYRIDOXINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

pyridoxal hydrochloride (58-56-0) + acetic anhydride (108-24-7) → pyridoxine triacetate (10030-93-0)

Guidance literature:

With triethylamine; In tert-butyl methyl ether; at 50 - 65 ℃; for 2.5h; Industry scale; Heating / reflux;

Reference yield: 85.0%

2-Methyl-3-hydroxy-4,5-bis-(bromomethyl)-pyridine hydrobromide (39984-49-1) + acetic anhydride (108-24-7) → pyridoxine triacetate (10030-93-0)

Guidance literature:

2-Methyl-3-hydroxy-4,5-bis-(bromomethyl)-pyridine hydrobromide; acetic anhydride; In DMF (N,N-dimethyl-formamide); at 55 ℃; for 1h;

With sodium acetate; at 85 ℃; for 4h;

Reference yield: 68.0%

5-hydroxy-6-methyl-3,4-pyridinedimethanol (65-23-6) + acetic anhydride (108-24-7) → pyridoxine triacetate (10030-93-0)

Guidance literature:

With triethylamine; In dichloromethane; at 25 ℃; for 12h;

upstream raw materials:

pyridoxal hydrochloride

acetic anhydride

2-Methyl-3-hydroxy-4,5-bis-(bromomethyl)-pyridine hydrobromide

5-hydroxy-6-methyl-3,4-pyridinedimethanol

Downstream raw materials:

pyridoxal hydrochloride

pyridoxamine

Refernces

• 1、 Geiger,Lalonde,Stoller,Schleich. "Cobalt-catalyzed cycloaddition of alkynes and nitriles to pyridines: A new route to pyridoxine (vitamin B6)". . p. 1274 - 1282. Retrieved 1984.
• 2、 Baldessari, Alicia,Mangone, Constanza P.,Gros, Eduardo G.. "Lipase-catalyzed acylation and deacylation reactions of pyridoxine, a member of vitamin-B6 group". . p. 2407 - 2413. Retrieved 1998.
• 3、 -. "METHODS FOR THE SYNTHESIS OF PYRIDOXAMINE". Page/Page column 34-35. . Retrieved 2008/06/13.