4-[(3-chloro-2-fluoro-phenyl)amino]-6-[cis-4-(N-morpholinocarbonyl-N-methyl-amino)-cyclohexyl-oxy]-7-methoxy-quinazoline

Base Information

Chemical Name:4-[(3-chloro-2-fluoro-phenyl)amino]-6-[cis-4-(N-morpholinocarbonyl-N-methyl-amino)-cyclohexyl-oxy]-7-methoxy-quinazoline
CAS No.:1024015-16-4
Molecular Formula:C₂₇H₃₁ClFN₅O₄
Molecular Weight:544.026
Hs Code.:

Synonyms:4-[(3-chloro-2-fluoro-phenyl)amino]-6-[cis-4-(N-morpholinocarbonyl-N-methyl-amino)-cyclohexyl-oxy]-7-methoxy-quinazoline

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Chemical Property of 4-[(3-chloro-2-fluoro-phenyl)amino]-6-[cis-4-(N-morpholinocarbonyl-N-methyl-amino)-cyclohexyl-oxy]-7-methoxy-quinazoline

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Technology Process of 4-[(3-chloro-2-fluoro-phenyl)amino]-6-[cis-4-(N-morpholinocarbonyl-N-methyl-amino)-cyclohexyl-oxy]-7-methoxy-quinazoline

There total 7 articles about 4-[(3-chloro-2-fluoro-phenyl)amino]-6-[cis-4-(N-morpholinocarbonyl-N-methyl-amino)-cyclohexyl-oxy]-7-methoxy-quinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-chloro-6-[cis-4-(N-morpholinocarbonyl-N-methyl-amino)-cyclohexyl-oxy]-7-methoxy-quinazoline hydrochloride

: 2106-04-9
3-chloro-2-fluoroaniline

: 1024015-16-4
4-[(3-chloro-2-fluoro-phenyl)amino]-6-[cis-4-(N-morpholinocarbonyl-N-methyl-amino)-cyclohexyl-oxy]-7-methoxy-quinazoline

Guidance literature:: 4-chloro-6-[cis-4-(N-morpholinocarbonyl-N-methyl-amino)-cyclohexyl-oxy]-7-methoxy-quinazoline hydrochloride; 3-chloro-2-fluoroaniline; In isopropyl alcohol; for 1.5h; Reflux;

With potassium carbonate; In water; ethyl acetate;

Reference yield:

: 179688-53-0
6-acetoxy-7-methoxy-3,4-dihydroquinazolin-4-one

: 1024015-16-4
4-[(3-chloro-2-fluoro-phenyl)amino]-6-[cis-4-(N-morpholinocarbonyl-N-methyl-amino)-cyclohexyl-oxy]-7-methoxy-quinazoline

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium carbonate / acetone / 8 h / 35 - 40 °C

2.1: sodium hydroxide; water / ethanol / 1 h / 20 - 30 °C

2.2: 20 h / 20 °C

3.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 100 - 120 °C

4.1: hydrogenchloride / isopropyl alcohol; ethanol / 40 °C

5.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C / Cooling with ice

6.1: hydrogen / palladium 10% on activated carbon / acetic acid / 80 °C / 775.74 Torr

7.1: thionyl chloride / N,N-dimethyl-formamide / 3 h / Reflux

8.1: isopropyl alcohol / 1.5 h / Reflux

With hydrogenchloride; thionyl chloride; water; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; palladium 10% on activated carbon; N,N-dimethyl-formamide; In 1-methyl-pyrrolidin-2-one; ethanol; acetic acid; isopropyl alcohol; acetone; acetonitrile;

Reference yield:

: 941598-33-0
3-benzyl-3,4-dihydro-4-oxo-6-{cis-4-[N-(tert-butyloxycarbonyl)-N-methyl-amino]-cyclohexyl-oxy}-7-methoxy-quinazoline

: 1024015-16-4
4-[(3-chloro-2-fluoro-phenyl)amino]-6-[cis-4-(N-morpholinocarbonyl-N-methyl-amino)-cyclohexyl-oxy]-7-methoxy-quinazoline

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride / isopropyl alcohol; ethanol / 40 °C

2: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C / Cooling with ice

3: hydrogen / palladium 10% on activated carbon / acetic acid / 80 °C / 775.74 Torr

4: thionyl chloride / N,N-dimethyl-formamide / 3 h / Reflux

5: isopropyl alcohol / 1.5 h / Reflux

With hydrogenchloride; thionyl chloride; hydrogen; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; N,N-dimethyl-formamide; In ethanol; acetic acid; isopropyl alcohol; acetonitrile;