-METHYL-2-TRIFLUOROMETHYLBENZYL BROMIDE

Base Information

• Chemical Name: -METHYL-2-TRIFLUOROMETHYLBENZYL BROMIDE
• CAS No.: 1997-80-4
• Molecular Formula: C9H8 Br F3
• Molecular Weight: 253.062
• Hs Code.: 2903999090
• Mol file: 1997-80-4.mol

Synonyms:Toluene,m-(2-bromoethyl)-a,a,a-trifluoro- (7CI,8CI);1-(2-Bromoethyl)-3-(trifluoromethyl)benzene; 3-Trifluoromethylphenethyl bromide

Chemical Property of -METHYL-2-TRIFLUOROMETHYLBENZYL BROMIDE

Chemical Property:

• Refractive Index: n20/D 1.486
• Boiling Point: 92-94 °C/12 mmHg
• PSA: 0.00000
• Density: 1.495 g/mL at 25 °C
• LogP: 3.64280
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-(2-Bromoethyl)-3-(trifluoromethyl)benzene ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn,N
• Statements: 34-36/37/38-51/53-36-22
• Safety Statements: 26-36/37/39-61

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of -METHYL-2-TRIFLUOROMETHYLBENZYL BROMIDE

There total 6 articles about -METHYL-2-TRIFLUOROMETHYLBENZYL BROMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-[3-(trifluoromethyl)phenyl]ethanol (455-01-6) → 2-(3-trifluoromethylphenyl)-ethyl bromide (1997-80-4)

Guidance literature:

With sulfuric acid; hydrogen bromide; Heating;

DOI:10.1016/0223-5234(93)90086-T

Reference yield:

3-(trifluoromethyl)phenylacetic acid (351-35-9) → 2-(3-trifluoromethylphenyl)-ethyl bromide (1997-80-4)

Guidance literature:

Multi-step reaction with 3 steps

2: LiAlH₄

3: PBr₃

With lithium aluminium tetrahydride; phosphorus tribromide;

DOI:10.1021/ja00451a035

Reference yield:

(3-trifluoromethyl-phenyl)-acetic acid methyl ester (62451-84-7) → 2-(3-trifluoromethylphenyl)-ethyl bromide (1997-80-4)

Guidance literature:

Multi-step reaction with 2 steps

1: LiAlH₄

2: PBr₃

With lithium aluminium tetrahydride; phosphorus tribromide;

DOI:10.1021/ja00451a035

upstream raw materials:

2-[3-(trifluoromethyl)phenyl]ethanol

3-(trifluoromethyl)phenylacetic acid

(3-trifluoromethyl-phenyl)-acetic acid methyl ester

3-Trifluoromethylbenzyl chloride

Downstream raw materials:

3-[(N-(2-(3-Trifluoromethylphenyl)-ethyl)-piperidin-3-yl)methyl]-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one-hydrochloride

2,4,6-trimethyl-N-((3'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl)methyl)-N-(3-(trifluoromethyl)phenethyl)-benzenesulfonamide

2-(3-trifluoromethylphenyl)ethylamine

5-nitro-1-(3-(trifluoromethyl)phenethyl)-1H-indole

Refernces

• 1、 Caldirola, P.,Zandberg, P.,Mannhold, R.,Timmerman, H.. "New prenylamine-analogues: investigations of their influence on calcium-dependent biological systems". . p. 555 - 568. Retrieved 2007/10/02.