455-01-6Relevant articles and documents
Antiproliferative activity and SARs of caffeic acid esters with mono-substituted phenylethanols moiety
Xie, Jin,Yang, Fengzhi,Zhang, Man,Lam, Celine,Qiao, Yixue,Xiao, Jia,Zhang, Dongdong,Ge, Yuxuan,Fu, Lei,Xie, Dongsheng
, p. 131 - 134 (2016/12/27)
A series of CAPE derivatives with mono-substituted phenylethanols moiety were synthesized and evaluated by MTT assay on growth of 4 human cancer cell lines (Hela, DU-145, MCF-7 and ECA-109). The substituent effects on the antiproliferative activity were systematically investigated for the first time. It was found that electron-donating and hydrophobic substituents at 2′-position of phenylethanol moiety could significantly enhance CAPE's antiproliferative activity. 2′-Propoxyl derivative, as a novel caffeic acid ester, exhibited exquisite potency (IC50?=?0.4?±?0.02 & 0.6?±?0.03?μM against Hela and DU-145 respectively).
Markovnikov-Selective, Activator-Free Iron-Catalyzed Vinylarene Hydroboration
Macnair, Alistair J.,Millet, Clément R. P.,Nichol, Gary S.,Ironmonger, Alan,Thomas, Stephen P.
, p. 7217 - 7221 (2016/10/14)
Two series of structurally related alkoxy-tethered NHC iron(II) complexes have been developed as catalysts for the regioselective hydroboration of alkenes. Significantly, Markonikov-selective alkene hydroboration with HBpin has been controllably achieved using an iron catalyst (11 examples, 35-90% isolated yield) with up to 37:1 branched:linear selectivity. anti-Markovnikov-selective alkene hydroboration was also achieved using HBcat and modification of the ligand backbone (6 examples, 44-71% yields). In both cases, ligand design has enabled activator-free low-oxidation-state iron catalysis.
DEPROTECTION OF BOC-PROTECTED COMPOUNDS
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Page/Page column 2, (2010/12/29)
Organic compounds having t-butyl ester or BOC carbonate protecting groups are effectively deprotected by heating in a fluorinated alcohol solution.
