5-[(6,7-dichloro-1-oxo-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl)methyl]-2-fluorobenzoic acid

Base Information

Chemical Name:5-[(6,7-dichloro-1-oxo-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl)methyl]-2-fluorobenzoic acid
CAS No.:959771-66-5
Molecular Formula:C₁₅H₉Cl₂FN₂O₃
Molecular Weight:355.152
Hs Code.:

Synonyms:5-[(6,7-dichloro-1-oxo-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl)methyl]-2-fluorobenzoic acid

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Chemical Property of 5-[(6,7-dichloro-1-oxo-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl)methyl]-2-fluorobenzoic acid

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Technology Process of 5-[(6,7-dichloro-1-oxo-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl)methyl]-2-fluorobenzoic acid

There total 7 articles about 5-[(6,7-dichloro-1-oxo-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl)methyl]-2-fluorobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 27746-03-8
4-chloro-1H-pyrrole-2-carboxylic acid

: 959771-66-5
5-[(6,7-dichloro-1-oxo-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl)methyl]-2-fluorobenzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: dicyclohexyl-carbodiimide / tetrahydrofuran / 12 h / 20 °C

2.1: sodium hydrogencarbonate / water; acetonitrile / 12 h / Heating / reflux

3.1: N-chloro-succinimide / tetrahydrofuran / 20 °C

4.1: sodium hydroxide; water / 8 h / 90 °C / Heating / reflux

4.2: 0.5 h / 0 - 20 °C

With sodium hydroxide; N-chloro-succinimide; water; sodium hydrogencarbonate; dicyclohexyl-carbodiimide; In tetrahydrofuran; water; acetonitrile;

Reference yield:

: 5-[(6,7-dichloro-1-oxo-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl)methyl]-2-fluorobenzonitrile

: 959771-66-5
5-[(6,7-dichloro-1-oxo-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl)methyl]-2-fluorobenzoic acid

Guidance literature:: With water; sodium hydroxide; Reflux;
DOI:10.1016/j.bmcl.2009.12.026

Reference yield:

: 959771-57-4
3-(3-cyano-4-fluorophenyl)-N-(2,4-dimethoxybenzyl)prop-2-yn-1-aminium chloride

: 959771-66-5
5-[(6,7-dichloro-1-oxo-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl)methyl]-2-fluorobenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / water; acetonitrile / 12 h / Heating / reflux

2.1: N-chloro-succinimide / tetrahydrofuran / 20 °C

3.1: sodium hydroxide; water / 8 h / 90 °C / Heating / reflux

3.2: 0.5 h / 0 - 20 °C

With sodium hydroxide; N-chloro-succinimide; water; sodium hydrogencarbonate; In tetrahydrofuran; water; acetonitrile;