7-N,N-Dimethylglycylpaclitaxel

Base Information

Chemical Name:7-N,N-Dimethylglycylpaclitaxel
CAS No.:131966-77-3
Molecular Formula:C₅₁H₅₈N₂O₁₅
Molecular Weight:939.026
Hs Code.:
ChEMBL ID:CHEMBL1185328
DSSTox Substance ID:DTXSID601306831

Synonyms:7-N,N-Dimethylglycylpaclitaxel;CHEMBL1185328;DTXSID601306831;131966-77-3

Suppliers and Price of 7-N,N-Dimethylglycylpaclitaxel

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of 7-N,N-Dimethylglycylpaclitaxel

Chemical Property:

XLogP3:3.1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:16
Rotatable Bond Count:18
Exact Mass:938.38371915
Heavy Atom Count:68
Complexity:1980

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)OC(=O)CN(C)C)C)OC(=O)C
Isomeric SMILES:CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)OC(=O)CN(C)C)C)OC(=O)C

Technology Process of 7-N,N-Dimethylglycylpaclitaxel

There total 3 articles about 7-N,N-Dimethylglycylpaclitaxel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 131966-76-2
2'-troc-7-(N,N-dimethylglycyl)taxol

: 131966-77-3
7-(N,N-dimethylglycyl)taxol

Guidance literature:: With acetic acid; zinc; In methanol; for 0.416667h; Ambient temperature;
DOI:10.1021/jm00079a019

Reference yield:

: 100431-55-8
2'-<<(trichloroethyl)oxy>carbonyl>taxol

: 131966-77-3
7-(N,N-dimethylglycyl)taxol

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / DCC, DMAP / CH₂Cl₂ / 48 h / Ambient temperature

2: 68 percent / Zn, CH₃COOH / methanol / 0.42 h / Ambient temperature

With dmap; acetic acid; dicyclohexyl-carbodiimide; zinc; In methanol; dichloromethane;
DOI:10.1021/jm00079a019

Reference yield:

: 33069-62-4
taxol

: 131966-77-3
7-(N,N-dimethylglycyl)taxol

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / pyridine / CH₂Cl₂

2: 89 percent / DCC, DMAP / CH₂Cl₂ / 48 h / Ambient temperature

3: 68 percent / Zn, CH₃COOH / methanol / 0.42 h / Ambient temperature

With pyridine; dmap; acetic acid; dicyclohexyl-carbodiimide; zinc; In methanol; dichloromethane;
DOI:10.1021/jm00079a019