4-(4-Halophenyl)-1,2,3,6-terahydropyridinehydrochloride

Base Information

• Chemical Name: 4-(4-Halophenyl)-1,2,3,6-terahydropyridinehydrochloride
• CAS No.: 1978-59-2
• Molecular Formula: C11H12 F N
• Molecular Weight: 177.221
• Hs Code.: 2933399090
• Mol file: 1978-59-2.mol

Synonyms:Pyridine,4-(p-fluorophenyl)-1,2,3,6-tetrahydro- (6CI,7CI,8CI);4-(4-Fluorophenyl)-1,2,3,6-tetrahydropyridine; 4-(p-Fluorophenyl)-1,2,3,6-tetrahydropyridine

Chemical Property of 4-(4-Halophenyl)-1,2,3,6-terahydropyridinehydrochloride

Chemical Property:

• Vapor Pressure: 0.00997mmHg at 25°C
• Refractive Index: 1.534
• Boiling Point: 264°Cat760mmHg
• PKA: 9.34±0.10(Predicted)
• Flash Point: 113.4°C
• PSA: 12.03000
• Density: 1.092g/cm³
• LogP: 2.53120

Purity/Quality:

98%Min ^*data from raw suppliers

4-(4-FLUOROPHENYL)-1,2,3,6-TETRAHYDRO-PYRIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(4-Halophenyl)-1,2,3,6-terahydropyridinehydrochloride

There total 18 articles about 4-(4-Halophenyl)-1,2,3,6-terahydropyridinehydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-(4-fluorophenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester (138647-52-6) → 4-(p-fluorophenyl)-1,2,3,6-tetrahydropyridine (1978-59-2)

Guidance literature:

With hydrogenchloride; In diethyl ether; dichloromethane; at 20 ℃;

Reference yield: 93.0%

4-(4-Fluoro-phenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid 2,2,2-trichloro-ethyl ester (163630-90-8) → 4-(p-fluorophenyl)-1,2,3,6-tetrahydropyridine (1978-59-2)

Guidance literature:

With acetic acid; zinc; In water; at 45 ℃;

DOI:10.1021/jm00011a019

Reference yield: 69.0%

acetic acid 2-[4-(4-fluoro-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-ethyl ester → 4-(p-fluorophenyl)-1,2,3,6-tetrahydropyridine (1978-59-2)

Guidance literature:

With bis(p-methoxyphenyl)methanone; water; In acetonitrile; for 3h; Irradiation;

DOI:10.1016/S0040-4039(00)00108-8

upstream raw materials:

2-(4-fluorophenyl)-1-propene

4-(4-Fluoro-phenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid 2,2,2-trichloro-ethyl ester

4-fluoroboronic acid

N-tert-butyloxycarbonylpiperidin-4-one

Downstream raw materials:

4-bromo-4-(4-fluoro-phenyl)-piperidine; hydrobromide

3-{4-[4-(4-fluorophenyl)-1-(1,2,3,6-tetrahydro)pyridinyl]-1-butyl}-1H-indole

2-{4-[4-(4-fluoro-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-butyrylamino}-benzamide

5-[4-(4-fluoro-phenyl)-3,6-dihydro-2H-pyridin-1-ylmethyl]-pyrimidine-2,4-diamine

Refernces

• 1、 Toscani, Anita,Risi, Caterina,Black, Gary W.,Brown, Nicola L.,Shaaban, Ali,Turner, Nicholas J.,Castagnolo, Daniele. "Monoamine Oxidase (MAO-N) Whole Cell Biocatalyzed Aromatization of 1,2,5,6-Tetrahydropyridines into Pyridines". . p. 8781 - 8787. Retrieved 2018/09/06.
• 2、 Kim, Eunkyung,Park, Chan Sun,Han, Taedong,Bae, Myung-Ho,Chong, Wonee,Lee, Choong Hyun,Shin, Young Ah,Ahn, Byung-Nak,Kim, Mi Kyung,Shin, Chang Yell,Son, Moon Ho,Kim, Jin Kwan,Moon, Ho Sang,Shim, Hyun Joo,Kim, Eun Jung,Kim, Soon Hoe,Lim, Joong In,Lee, Chun Ho. "Design, synthesis, and evaluation of novel aryl-tetrahydropyridine PPARα/γ dual agonists". scheme or table. p. 4993 - 4996. Retrieved 2009/05/26.