4-(4-Fluoro-phenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid 2,2,2-trichloro-ethyl ester

Base Information

Chemical Name:4-(4-Fluoro-phenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid 2,2,2-trichloro-ethyl ester
CAS No.:163630-90-8
Molecular Formula:C₁₄H₁₃Cl₃FNO₂
Molecular Weight:352.62
Hs Code.:

Synonyms:4-(4-Fluoro-phenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid 2,2,2-trichloro-ethyl ester

Suppliers and Price of 4-(4-Fluoro-phenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid 2,2,2-trichloro-ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 4-(4-Fluoro-phenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid 2,2,2-trichloro-ethyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-(4-Fluoro-phenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid 2,2,2-trichloro-ethyl ester

There total 4 articles about 4-(4-Fluoro-phenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid 2,2,2-trichloro-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 163630-89-5
4-(4-fluorophenyl)-1,2,3,6-tetrahydro-1-(phenylmethyl)pyridine

: 17341-93-4
2,2,2-Trichloroethyl chloroformate

: 163630-90-8
4-(4-Fluoro-phenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid 2,2,2-trichloro-ethyl ester

Guidance literature:: In 1,1,1-trichloroethane; for 3h; Heating;
DOI:10.1021/jm00011a019

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 163630-90-8
4-(4-Fluoro-phenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid 2,2,2-trichloro-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) n-BuLi / 1.) n-hexane, diethyl ether, -50 deg C, 40 min, 2.) n-hexane, diethyl ether, from -50 deg C to -10 deg C

2: 96 percent / trifluoroacetic acid / 1.5 h / Heating

3: 93 percent / 1,1,1-trichloro-ethane / 3 h / Heating

With n-butyllithium; trifluoroacetic acid; In 1,1,1-trichloroethane;
DOI:10.1021/jm00011a019

Reference yield:

: 163631-02-5
1-benzyl-4-(4-fluorophenyl)-4-hydroxypiperidine

: 163630-90-8
4-(4-Fluoro-phenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid 2,2,2-trichloro-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / trifluoroacetic acid / 1.5 h / Heating

2: 93 percent / 1,1,1-trichloro-ethane / 3 h / Heating

With trifluoroacetic acid; In 1,1,1-trichloroethane;
DOI:10.1021/jm00011a019