(2-benzyl-4-{4-[1-(tetrahydrofuran-3-carbonyl)pyrrolidin-3-yl]piperazin-1-yl}piperidin-1-yl)-(3,5-trifluoromethyl-phenyl)methanone

Base Information

Chemical Name:(2-benzyl-4-{4-[1-(tetrahydrofuran-3-carbonyl)pyrrolidin-3-yl]piperazin-1-yl}piperidin-1-yl)-(3,5-trifluoromethyl-phenyl)methanone
CAS No.:871902-99-7
Molecular Formula:C₃₄H₄₀F₆N₄O₃
Molecular Weight:666.707
Hs Code.:

Synonyms:(2-benzyl-4-{4-[1-(tetrahydrofuran-3-carbonyl)pyrrolidin-3-yl]piperazin-1-yl}piperidin-1-yl)-(3,5-trifluoromethyl-phenyl)methanone

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Chemical Property of (2-benzyl-4-{4-[1-(tetrahydrofuran-3-carbonyl)pyrrolidin-3-yl]piperazin-1-yl}piperidin-1-yl)-(3,5-trifluoromethyl-phenyl)methanone

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Technology Process of (2-benzyl-4-{4-[1-(tetrahydrofuran-3-carbonyl)pyrrolidin-3-yl]piperazin-1-yl}piperidin-1-yl)-(3,5-trifluoromethyl-phenyl)methanone

There total 8 articles about (2-benzyl-4-{4-[1-(tetrahydrofuran-3-carbonyl)pyrrolidin-3-yl]piperazin-1-yl}piperidin-1-yl)-(3,5-trifluoromethyl-phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 89364-31-8
3-tetrahydrofuroic acid

: 717923-55-2
C₂₉H₃₄F₆N₄O

: 871902-99-7
(2-benzyl-4-{4-[1-(tetrahydrofuran-3-carbonyl)pyrrolidin-3-yl]piperazin-1-yl}piperidin-1-yl)-(3,5-trifluoromethyl-phenyl)methanone

Guidance literature:: 3-tetrahydrofuroic acid; With 1,1'-carbonyldiimidazole; In dichloromethane; at 20 - 40 ℃; for 3.75h;

C₂₉H₃₄F₆N₄O; In dichloromethane; at 20 ℃;

Reference yield:

: 717923-54-1
C₃₆H₄₀F₆N₄O

: 871902-99-7
(2-benzyl-4-{4-[1-(tetrahydrofuran-3-carbonyl)pyrrolidin-3-yl]piperazin-1-yl}piperidin-1-yl)-(3,5-trifluoromethyl-phenyl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen / 10% palladium on activated carbon / methanol

2.1: 1,1'-carbonyldiimidazole / dichloromethane / 3.75 h / 20 - 40 °C

2.2: 20 °C

With hydrogen; 1,1'-carbonyldiimidazole; 10% palladium on activated carbon; In methanol; dichloromethane;

Reference yield:

: 681291-90-7
C₂₃H₂₁F₆NO₃

: 871902-99-7
(2-benzyl-4-{4-[1-(tetrahydrofuran-3-carbonyl)pyrrolidin-3-yl]piperazin-1-yl}piperidin-1-yl)-(3,5-trifluoromethyl-phenyl)methanone

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride; ethanol; water / 20 h / 60 °C

2.1: CHIRALPAK AS / hexane; isopropyl alcohol / Resolution of racemate

3.1: titanium(IV) isopropylate / 2 h / 40 °C

3.2: 20 - 50 °C

3.3: 0.25 h

4.1: hydrogen / thiophene; 10% palladium on activated carbon / methanol / 50 °C

5.1: hydrogen / 10% palladium on activated carbon / methanol

6.1: 1,1'-carbonyldiimidazole / dichloromethane / 3.75 h / 20 - 40 °C

6.2: 20 °C

With titanium(IV) isopropylate; hydrogenchloride; ethanol; CHIRALPAK AS; water; hydrogen; 1,1'-carbonyldiimidazole; thiophene; 10% palladium on activated carbon; In methanol; hexane; dichloromethane; isopropyl alcohol;