1-(3,4-dimethoxy)benzyl-1,2,3,4-tetrahydro-6-benzyloxy-7-methoxyisoquinoline

Base Information

• Chemical Name: 1-(3,4-dimethoxy)benzyl-1,2,3,4-tetrahydro-6-benzyloxy-7-methoxyisoquinoline
• CAS No.: 54881-16-2
• Molecular Formula: C₂₆H₂₉NO₄
• Molecular Weight: 419.521
• Mol file: 54881-16-2.mol

Synonyms:1-(3,4-dimethoxy)benzyl-1,2,3,4-tetrahydro-6-benzyloxy-7-methoxyisoquinoline

Chemical Property of 1-(3,4-dimethoxy)benzyl-1,2,3,4-tetrahydro-6-benzyloxy-7-methoxyisoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(3,4-dimethoxy)benzyl-1,2,3,4-tetrahydro-6-benzyloxy-7-methoxyisoquinoline

There total 4 articles about 1-(3,4-dimethoxy)benzyl-1,2,3,4-tetrahydro-6-benzyloxy-7-methoxyisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[1-[(S)-6-Benzyloxy-1-(3,4-dimethoxy-benzyl)-7-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-meth-(E)-ylidene]-((S)-1-tert-butoxymethyl-2-methyl-propyl)-amine → (S)-6-Benzyloxy-1-(3,4-dimethoxy-benzyl)-7-methoxy-1,2,3,4-tetrahydro-isoquinoline (54881-16-2,87896-86-4)

Guidance literature:

With hydrazine; In ethanol; acetic acid; at 50 ℃;

DOI:10.1016/S0040-4020(01)87686-9

Reference yield:

6-(Benzyloxy)-7-methoxy-1,2,3,4-tetrahydroisoquinoline (98809-69-9) → (S)-6-Benzyloxy-1-(3,4-dimethoxy-benzyl)-7-methoxy-1,2,3,4-tetrahydro-isoquinoline (54881-16-2,87896-86-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent / toluene / 16 °C / Heating

2: 1) t-butyllithium / 1) THF, pentane, -100 deg C, 0.5 h, 2) THF, pentane, -100 deg C, 0.5 h

3: hidrazine / aq. ethanol; acetic acid / 50 °C

With tert.-butyl lithium; hydrazine; In ethanol; acetic acid; toluene;

DOI:10.1016/S0040-4020(01)87686-9

Reference yield:

(S)-valino tert-butyl ether formamidine of 3-benzyloxy-4-methoxy-1,2,3,4-tetrahydro-isoquinoline (116195-54-1) → (S)-6-Benzyloxy-1-(3,4-dimethoxy-benzyl)-7-methoxy-1,2,3,4-tetrahydro-isoquinoline (54881-16-2,87896-86-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) t-butyllithium / 1) THF, pentane, -100 deg C, 0.5 h, 2) THF, pentane, -100 deg C, 0.5 h

2: hidrazine / aq. ethanol; acetic acid / 50 °C

With tert.-butyl lithium; hydrazine; In ethanol; acetic acid;

DOI:10.1016/S0040-4020(01)87686-9

upstream raw materials:

6-(Benzyloxy)-7-methoxy-1,2,3,4-tetrahydroisoquinoline

(S)-valino tert-butyl ether formamidine of 3-benzyloxy-4-methoxy-1,2,3,4-tetrahydro-isoquinoline

Downstream raw materials:

(S)-(+)-1-(3',4'-dimethoxybenzyl)-6-benzyloxy-7-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinoline

N-ethoxycarbonyl-1-(3,4-dimethoxy)benzyl-1,2,3,4-tetrahydro-6-benzyloxy-7-methoxyisoquinoline

N-acetyl-1-(3,4-dimethoxy)benzyl-1,2,3,4-tetrahydro-6-benzyloxy-7-methoxyisoquinoline

N-methanesulfonyl-1-(3,4-dimethoxy)benzyl-1,2,3,4-tetrahydro-6-benzyloxy-7-methoxyisoquinoline