N-methanesulfonyl-1-(3,4-dimethoxy)benzyl-1,2,3,4-tetrahydro-6-benzyloxy-7-methoxyisoquinoline

Base Information

• Chemical Name: N-methanesulfonyl-1-(3,4-dimethoxy)benzyl-1,2,3,4-tetrahydro-6-benzyloxy-7-methoxyisoquinoline
• CAS No.: 329772-74-9
• Molecular Formula: C₂₇H₃₁NO₆S
• Molecular Weight: 497.612
• Mol file: 329772-74-9.mol

Synonyms:N-methanesulfonyl-1-(3,4-dimethoxy)benzyl-1,2,3,4-tetrahydro-6-benzyloxy-7-methoxyisoquinoline

Chemical Property of N-methanesulfonyl-1-(3,4-dimethoxy)benzyl-1,2,3,4-tetrahydro-6-benzyloxy-7-methoxyisoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-methanesulfonyl-1-(3,4-dimethoxy)benzyl-1,2,3,4-tetrahydro-6-benzyloxy-7-methoxyisoquinoline

There total 1 articles about N-methanesulfonyl-1-(3,4-dimethoxy)benzyl-1,2,3,4-tetrahydro-6-benzyloxy-7-methoxyisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-(3,4-dimethoxy)benzyl-1,2,3,4-tetrahydro-6-benzyloxy-7-methoxyisoquinoline (54881-16-2) + methanesulfonyl chloride (124-63-0) → N-methanesulfonyl-1-(3,4-dimethoxy)benzyl-1,2,3,4-tetrahydro-6-benzyloxy-7-methoxyisoquinoline (329772-74-9)

Guidance literature:

With potassium carbonate; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1016/S0040-4020(00)00934-0

Reference yield: 84.0%

N-methanesulfonyl-1-(3,4-dimethoxy)benzyl-1,2,3,4-tetrahydro-6-benzyloxy-7-methoxyisoquinoline (329772-74-9) → N-methanesulfonyl-1-(3,4-dimethoxy)benzyl-1,2,3,4-tetrahydro-7-methoxyisoquinolin-6-ol (329772-79-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; at 20 ℃; for 2h; under 760 Torr;

DOI:10.1016/S0040-4020(00)00934-0

Reference yield:

N-methanesulfonyl-1-(3,4-dimethoxy)benzyl-1,2,3,4-tetrahydro-6-benzyloxy-7-methoxyisoquinoline (329772-74-9) → N-methanesulfonyl-1-(3,4-dimethoxy)benzyl-7-acetoxy-1,2,3,4,6,7-hexahydro-7-methoxy-6-oxoisoquinoline (329772-84-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / H₂ / Pd/C / ethyl acetate / 2 h / 20 °C / 760 Torr

2: CH₂Cl₂ / 0.5 h

With hydrogen; palladium on activated charcoal; In dichloromethane; ethyl acetate;

DOI:10.1016/S0040-4020(00)00934-0

upstream raw materials:

1-(3,4-dimethoxy)benzyl-1,2,3,4-tetrahydro-6-benzyloxy-7-methoxyisoquinoline

methanesulfonyl chloride

Downstream raw materials:

N-methanesulfonyl-1-(3,4-dimethoxy)benzyl-1,2,3,4-tetrahydro-7-methoxyisoquinolin-6-ol

N-methanesulfonyl-1-(3,4-dimethoxy)benzyl-7-acetoxy-1,2,3,4,6,7-hexahydro-7-methoxy-6-oxoisoquinoline