({(S)-6-Amino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-indan-2-yl-amino)-acetic acid

Base Information

Chemical Name:({(S)-6-Amino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-indan-2-yl-amino)-acetic acid
CAS No.:126110-46-1
Molecular Formula:C₂₇H₃₇N₂O₆P
Molecular Weight:516.574
Hs Code.:

Synonyms:({(S)-6-Amino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-indan-2-yl-amino)-acetic acid

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Chemical Property of ({(S)-6-Amino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-indan-2-yl-amino)-acetic acid

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Technology Process of ({(S)-6-Amino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-indan-2-yl-amino)-acetic acid

There total 7 articles about ({(S)-6-Amino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-indan-2-yl-amino)-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 126110-77-8
({(S)-6-Benzyloxycarbonylamino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-indan-2-yl-amino)-acetic acid benzyl ester

: 126110-46-1
({(S)-6-Amino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-indan-2-yl-amino)-acetic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 3h; Yield given;
DOI:10.1021/jm00167a028

Reference yield:

: 86552-32-1
(4-phenylbutyl)phosphinic acid

: 126110-46-1
({(S)-6-Amino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-indan-2-yl-amino)-acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 5.77 g / N,N'-dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / tetrahydrofuran / 0.67 h / Ambient temperature

2: NaIO₄ / dioxane; H₂O / 16 h / Ambient temperature

3: 99 percent / 2.0 N NaOH / dioxane / 2 h / Ambient temperature

4: 69 percent / triethylamine, N,N'-dicyclohexylcarbodiimide / tetrahydrofuran / 6 h / Ambient temperature

5: H₂ / 20percent Pd/C / methanol / 3 h

With dmap; sodium hydroxide; sodium periodate; hydrogen; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; water;
DOI:10.1021/jm00167a028

Reference yield:

: 59221-35-1
(S)-6-[[(Phenylmethoxy)carbonyl]amino]-2-hydroxyhexanoic acid

: 126110-46-1
({(S)-6-Amino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-indan-2-yl-amino)-acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 88 percent / potassium carbonate / dimethylformamide / 2 h / Ambient temperature

2: 5.77 g / N,N'-dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / tetrahydrofuran / 0.67 h / Ambient temperature

3: NaIO₄ / dioxane; H₂O / 16 h / Ambient temperature

4: 99 percent / 2.0 N NaOH / dioxane / 2 h / Ambient temperature

5: 69 percent / triethylamine, N,N'-dicyclohexylcarbodiimide / tetrahydrofuran / 6 h / Ambient temperature

6: H₂ / 20percent Pd/C / methanol / 3 h

With dmap; sodium hydroxide; sodium periodate; hydrogen; potassium carbonate; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00167a028