({(S)-6-Benzyloxycarbonylamino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-indan-2-yl-amino)-acetic acid benzyl ester

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Chemical Name:({(S)-6-Benzyloxycarbonylamino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-indan-2-yl-amino)-acetic acid benzyl ester
CAS No.:126110-77-8
Molecular Formula:C₄₂H₄₉N₂O₈P
Molecular Weight:740.833
Hs Code.:

Synonyms:({(S)-6-Benzyloxycarbonylamino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-indan-2-yl-amino)-acetic acid benzyl ester

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Chemical Property of ({(S)-6-Benzyloxycarbonylamino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-indan-2-yl-amino)-acetic acid benzyl ester

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Technology Process of ({(S)-6-Benzyloxycarbonylamino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-indan-2-yl-amino)-acetic acid benzyl ester

There total 6 articles about ({(S)-6-Benzyloxycarbonylamino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-indan-2-yl-amino)-acetic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 107492-16-0
(S)-2-<oxy>-6-<<(phenylmethoxy)carbonyl>amino>hexanoic acid

: 83356-18-7
N-(2,3-dihydro-1 H-inden-2-yl)-glycine benzyl ester hydrochloride

: 126110-77-8
({(S)-6-Benzyloxycarbonylamino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-indan-2-yl-amino)-acetic acid benzyl ester

Guidance literature:: With triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; for 6h; Ambient temperature;
DOI:10.1021/jm00167a028

Reference yield:

: 86552-32-1
(4-phenylbutyl)phosphinic acid

: 126110-77-8
({(S)-6-Benzyloxycarbonylamino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-indan-2-yl-amino)-acetic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 5.77 g / N,N'-dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / tetrahydrofuran / 0.67 h / Ambient temperature

2: NaIO₄ / dioxane; H₂O / 16 h / Ambient temperature

3: 99 percent / 2.0 N NaOH / dioxane / 2 h / Ambient temperature

4: 69 percent / triethylamine, N,N'-dicyclohexylcarbodiimide / tetrahydrofuran / 6 h / Ambient temperature

With dmap; sodium hydroxide; sodium periodate; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; water;
DOI:10.1021/jm00167a028

Reference yield:

: 59221-35-1
(S)-6-[[(Phenylmethoxy)carbonyl]amino]-2-hydroxyhexanoic acid

: 126110-77-8
({(S)-6-Benzyloxycarbonylamino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-indan-2-yl-amino)-acetic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / potassium carbonate / dimethylformamide / 2 h / Ambient temperature

2: 5.77 g / N,N'-dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / tetrahydrofuran / 0.67 h / Ambient temperature

3: NaIO₄ / dioxane; H₂O / 16 h / Ambient temperature

4: 99 percent / 2.0 N NaOH / dioxane / 2 h / Ambient temperature

5: 69 percent / triethylamine, N,N'-dicyclohexylcarbodiimide / tetrahydrofuran / 6 h / Ambient temperature

With dmap; sodium hydroxide; sodium periodate; potassium carbonate; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00167a028