(2E)-3-(3-hydroxy-4-methoxyphenyl)-N-(2-{[(2E)-3-(2-iodophenyl)prop-2-enoyl]amino}ethyl)-2-(3,4,5-trimethoxyphenyl)acrylamide

Base Information

Chemical Name:(2E)-3-(3-hydroxy-4-methoxyphenyl)-N-(2-{[(2E)-3-(2-iodophenyl)prop-2-enoyl]amino}ethyl)-2-(3,4,5-trimethoxyphenyl)acrylamide
CAS No.:1417698-31-7
Molecular Formula:C₃₀H₃₁IN₂O₇
Molecular Weight:658.49
Hs Code.:

Synonyms:(2E)-3-(3-hydroxy-4-methoxyphenyl)-N-(2-{[(2E)-3-(2-iodophenyl)prop-2-enoyl]amino}ethyl)-2-(3,4,5-trimethoxyphenyl)acrylamide

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Chemical Property of (2E)-3-(3-hydroxy-4-methoxyphenyl)-N-(2-{[(2E)-3-(2-iodophenyl)prop-2-enoyl]amino}ethyl)-2-(3,4,5-trimethoxyphenyl)acrylamide

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Technology Process of (2E)-3-(3-hydroxy-4-methoxyphenyl)-N-(2-{[(2E)-3-(2-iodophenyl)prop-2-enoyl]amino}ethyl)-2-(3,4,5-trimethoxyphenyl)acrylamide

There total 4 articles about (2E)-3-(3-hydroxy-4-methoxyphenyl)-N-(2-{[(2E)-3-(2-iodophenyl)prop-2-enoyl]amino}ethyl)-2-(3,4,5-trimethoxyphenyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1417698-30-6
tert-butyl (2-{[(2E)-3-(2-iodophenyl)prop-2-enoyl]amino}ethyl)carbamate

: 388566-86-7
(E)-3-(3’-hydroxy-4’-methoxyphenyl)-2-(3”,4”,5”-trimethoxyphenyl)-2-propenoic acid

: 1417698-31-7
(2E)-3-(3-hydroxy-4-methoxyphenyl)-N-(2-{[(2E)-3-(2-iodophenyl)prop-2-enoyl]amino}ethyl)-2-(3,4,5-trimethoxyphenyl)acrylamide

Guidance literature:: tert-butyl (2-{[(2E)-3-(2-iodophenyl)prop-2-enoyl]amino}ethyl)carbamate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

(E)-3-(3’-hydroxy-4’-methoxyphenyl)-2-(3”,4”,5”-trimethoxyphenyl)-2-propenoic acid; With potassium carbonate; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

: C₁₁H₁₃IN₂O

: 388566-86-7
(E)-3-(3’-hydroxy-4’-methoxyphenyl)-2-(3”,4”,5”-trimethoxyphenyl)-2-propenoic acid

: 1417698-31-7
(2E)-3-(3-hydroxy-4-methoxyphenyl)-N-(2-{[(2E)-3-(2-iodophenyl)prop-2-enoyl]amino}ethyl)-2-(3,4,5-trimethoxyphenyl)acrylamide

Guidance literature:: With potassium carbonate; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

: 90276-19-0
(E)-3-(2-Iodophenyl)propenoic acid

: 1417698-31-7
(2E)-3-(3-hydroxy-4-methoxyphenyl)-N-(2-{[(2E)-3-(2-iodophenyl)prop-2-enoyl]amino}ethyl)-2-(3,4,5-trimethoxyphenyl)acrylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / 2 h / Reflux

1.2: 18 h / 0 °C

2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3.1: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C

With thionyl chloride; potassium carbonate; trifluoroacetic acid; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In dichloromethane; N,N-dimethyl-formamide;