3-(2-(allylcarbamoyl)-4-nitrophenylthio)prop-2-ynyl-2-chloro-5-nitrobenzoate

Base Information

• Chemical Name: 3-(2-(allylcarbamoyl)-4-nitrophenylthio)prop-2-ynyl-2-chloro-5-nitrobenzoate
• CAS No.: 1253765-43-3
• Molecular Formula: C₂₀H₁₄ClN₃O₇S
• Molecular Weight: 475.866
• Mol file: 1253765-43-3.mol

Synonyms:3-(2-(allylcarbamoyl)-4-nitrophenylthio)prop-2-ynyl-2-chloro-5-nitrobenzoate

Chemical Property of 3-(2-(allylcarbamoyl)-4-nitrophenylthio)prop-2-ynyl-2-chloro-5-nitrobenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2-(allylcarbamoyl)-4-nitrophenylthio)prop-2-ynyl-2-chloro-5-nitrobenzoate

There total 1 articles about 3-(2-(allylcarbamoyl)-4-nitrophenylthio)prop-2-ynyl-2-chloro-5-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-allyl-5-nitrobenzo[d]isothiazol-3(2H)-one (1060674-64-7) + prop-2-ynyl 2-chloro-5-nitrobenzoate (82038-62-8) → 3-(2-(allylcarbamoyl)-4-nitrophenylthio)prop-2-ynyl-2-chloro-5-nitrobenzoate (1253765-43-3)

Guidance literature:

With silver(I) acetate; In N,N-dimethyl-formamide; at 70 ℃; for 26h; Sealed tube;

DOI:10.1039/c0cc00885k

Reference yield: 83.0%

3-(2-(allylcarbamoyl)-4-nitrophenylthio)prop-2-ynyl-2-chloro-5-nitrobenzoate (1253765-43-3) + 4-methoxyphenylboronic acid (5720-07-0) → 3-(4-methoxyphenyl)prop-2-ynyl-2-chloro-5-nitrobenzoate (1253765-52-4)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(I) 2-hydroxy-3-methylbenzoate; In 1,2-dimethoxyethane; at 40 - 45 ℃; for 16h; Inert atmosphere;

DOI:10.1039/c0cc00885k

Reference yield: 66.0%

3-(2-(allylcarbamoyl)-4-nitrophenylthio)prop-2-ynyl-2-chloro-5-nitrobenzoate (1253765-43-3) + m-nitrobenzene boronic acid (13331-27-6) → 3-(3-nitrophenyl)prop-2-ynyl-2-chloro-5-nitrobenzoate (1253765-56-8)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(I) 2-hydroxy-3-methylbenzoate; In 1,2-dimethoxyethane; at 40 - 45 ℃; for 16h; Inert atmosphere;

DOI:10.1039/c0cc00885k

upstream raw materials:

2-allyl-5-nitrobenzo[d]isothiazol-3(2H)-one

prop-2-ynyl 2-chloro-5-nitrobenzoate

Downstream raw materials:

3-(4-methoxyphenyl)prop-2-ynyl-2-chloro-5-nitrobenzoate

3-(3-nitrophenyl)prop-2-ynyl-2-chloro-5-nitrobenzoate