5-[3-(4-fluoro-phenyl)-5-hydroxymethyl-isoxazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid amide

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Chemical Name:5-[3-(4-fluoro-phenyl)-5-hydroxymethyl-isoxazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid amide
CAS No.:1254965-32-6
Molecular Formula:C₁₆H₁₅FN₄O₄
Molecular Weight:346.318
Hs Code.:

Synonyms:5-[3-(4-fluoro-phenyl)-5-hydroxymethyl-isoxazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid amide

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Chemical Property of 5-[3-(4-fluoro-phenyl)-5-hydroxymethyl-isoxazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid amide

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Technology Process of 5-[3-(4-fluoro-phenyl)-5-hydroxymethyl-isoxazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid amide

There total 7 articles about 5-[3-(4-fluoro-phenyl)-5-hydroxymethyl-isoxazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1254966-33-0
5-[3-(4-fluoro-phenyl)-5-hydroxymethyl-isoxazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid

: 1254965-32-6
5-[3-(4-fluoro-phenyl)-5-hydroxymethyl-isoxazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid amide

Guidance literature:: 5-[3-(4-fluoro-phenyl)-5-hydroxymethyl-isoxazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid; With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 60 ℃; for 1h;

With ammonium hydroxide; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 954230-39-8
3-(4-fluoro-phenyl)-5-methyl-isoxazole-4-carboxylic acid ethyl ester

: 1254965-32-6
5-[3-(4-fluoro-phenyl)-5-hydroxymethyl-isoxazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid amide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium ethanolate / ethanol / 1 h / Reflux

2.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 20 °C

2.2: 20 °C

3.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 5 - 20 °C / Inert atmosphere

4.1: sodium periodate; osmium(VIII) oxide; N-benzyl-N,N,N-triethylammonium chloride; water / 1,4-dioxane / 0.42 h / 120 °C / Microwave irradiation

5.1: methanol; sodium tetrahydroborate / 1 h / 20 °C

6.1: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C

7.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 1 h / 60 °C

7.2: 20 °C

With methanol; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; N-benzyl-N,N,N-triethylammonium chloride; water; sodium ethanolate; chloroformic acid ethyl ester; triethylamine; triphenylphosphine; 1,1'-carbonyldiimidazole; lithium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1240402-78-1
3-(4-fluoro-phenyl)-5-((E)-styryl)-isoxazole-4-carboxylic acid

: 1254965-32-6
5-[3-(4-fluoro-phenyl)-5-hydroxymethyl-isoxazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 20 °C

1.2: 20 °C

2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 5 - 20 °C / Inert atmosphere

3.1: sodium periodate; osmium(VIII) oxide; N-benzyl-N,N,N-triethylammonium chloride; water / 1,4-dioxane / 0.42 h / 120 °C / Microwave irradiation

4.1: methanol; sodium tetrahydroborate / 1 h / 20 °C

5.1: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C

6.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 1 h / 60 °C

6.2: 20 °C

With methanol; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; N-benzyl-N,N,N-triethylammonium chloride; water; chloroformic acid ethyl ester; triethylamine; triphenylphosphine; 1,1'-carbonyldiimidazole; lithium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide;