(S)-(-)-isopropyl methylphenylphosphinate

Base Information

• Chemical Name: (S)-(-)-isopropyl methylphenylphosphinate
• CAS No.: 13336-70-4
• Molecular Formula: C₁₀H₁₅O₂P
• Molecular Weight: 198.202
• Mol file: 13336-70-4.mol

Synonyms:(S)-(-)-isopropyl methylphenylphosphinate

Chemical Property of (S)-(-)-isopropyl methylphenylphosphinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-(-)-isopropyl methylphenylphosphinate

There total 11 articles about (S)-(-)-isopropyl methylphenylphosphinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

isopropyl alcohol (67-63-0,8013-70-5) + 6,11-dichloro-5,12-dimethyl-3,5-diphenyl-3,9-diphosphatricyclo[6.2.2.02,7]dodeca-5,11-diene-3,9-dioxide → (S)-(-)-isopropyl methylphenylphosphinate (13336-70-4) + 4,7-dichloro-3,6-dimethyl-1-phenyl-4a,8a-dihydro-2H-phosphinoline 1-oxide

Guidance literature:

In acetonitrile; at 26 ℃; for 1h; Irradiation;

DOI:10.1002/hc.10221

Reference yield: 66.0%

isopropyl alcohol (67-63-0,8013-70-5) → (S)-(-)-isopropyl methylphenylphosphinate (13336-70-4) + 5-chloro-4-methyl-2-phenyl-3a,7a-dihydro-isoindole-1,3-dione + 5-chloro-6-methyl-2-phenyl-3a,7a-dihydro-isoindole-1,3-dione

Guidance literature:

In acetonitrile; at 26 ℃; for 2h; Irradiation;

DOI:10.1016/S0022-328X(98)00855-9

Reference yield:

bromobenzene (108-86-1,52753-63-6) + (R)-(+)-isopropyl methylphosphinate (21204-48-8,29327-00-2,31355-96-1) → (S)-(-)-isopropyl methylphenylphosphinate (13336-70-4) + (R)-isopropoxy(methyl)phenylphosphine oxide (18944-66-6)

Guidance literature:

With triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; at 90 ℃; for 0.5h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1039/c39860001606

upstream raw materials:

bromobenzene

(R)-(+)-isopropyl methylphosphinate

D,L-Methylphenylphosphinsaeurecyanid

isopropyl alcohol

Downstream raw materials:

R(+)-benzyl methyl phenyl phosphine oxide

S(-)-benzyl methyl phenyl phosphine oxide