O,O-diisopropyl-α-azidobenzylphosphonate

Base Information

• Chemical Name: O,O-diisopropyl-α-azidobenzylphosphonate
• CAS No.: 131523-52-9
• Molecular Formula: C₁₃H₂₀N₃O₃P
• Molecular Weight: 297.294
• Mol file: 131523-52-9.mol

Synonyms:O,O-diisopropyl-α-azidobenzylphosphonate

Chemical Property of O,O-diisopropyl-α-azidobenzylphosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of O,O-diisopropyl-α-azidobenzylphosphonate

There total 5 articles about O,O-diisopropyl-α-azidobenzylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

Toluene-4-sulfonic acid (diisopropoxy-phosphoryl)-phenyl-methyl ester (131523-50-7) → O,O-diisopropyl-α-azidobenzylphosphonate (131523-52-9)

Guidance literature:

With sodium azide; In dimethyl sulfoxide; at 75 - 80 ℃;

Reference yield:

(Bromo-phenyl-methyl)-phosphonic acid diisopropyl ester (136052-59-0) → O,O-diisopropyl-α-azidobenzylphosphonate (131523-52-9)

Guidance literature:

With sodium azide; In water; N,N-dimethyl-formamide; at 140 ℃; for 12h;

DOI:10.1080/00397919108019793

Reference yield:

triisopropyl phosphite (116-17-6) → O,O-diisopropyl-α-azidobenzylphosphonate (131523-52-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / 12 h / 160 °C

2: 1.) NBS, 2.) benzoyl peroxide / 1.) CCl₄, 1 h, 2.) CCl₄, 60 deg C, 24 h

3: sodium azide / dimethylformamide; H₂O / 12 h / 140 °C

With N-Bromosuccinimide; sodium azide; Perbenzoic acid; In water; N,N-dimethyl-formamide;

DOI:10.1080/00397919108019793

upstream raw materials:

(Bromo-phenyl-methyl)-phosphonic acid diisopropyl ester

Toluene-4-sulfonic acid (diisopropoxy-phosphoryl)-phenyl-methyl ester

triisopropyl phosphite

diisopropyl benzylphosphonate

Downstream raw materials:

diisopropyl [amino(phenyl)methyl]phosphonate