Toluene-4-sulfonic acid (diisopropoxy-phosphoryl)-phenyl-methyl ester

Base Information

• Chemical Name: Toluene-4-sulfonic acid (diisopropoxy-phosphoryl)-phenyl-methyl ester
• CAS No.: 131523-50-7
• Molecular Formula: C₂₀H₂₇O₆PS
• Molecular Weight: 426.471
• Mol file: 131523-50-7.mol

Synonyms:Toluene-4-sulfonic acid (diisopropoxy-phosphoryl)-phenyl-methyl ester

Chemical Property of Toluene-4-sulfonic acid (diisopropoxy-phosphoryl)-phenyl-methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of Toluene-4-sulfonic acid (diisopropoxy-phosphoryl)-phenyl-methyl ester

There total 2 articles about Toluene-4-sulfonic acid (diisopropoxy-phosphoryl)-phenyl-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(hydroxy-phenyl-methyl)-phosphonic acid diisopropyl ester (20386-43-0) + p-toluenesulfonyl chloride (98-59-9) → Toluene-4-sulfonic acid (diisopropoxy-phosphoryl)-phenyl-methyl ester (131523-50-7)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1080/15257770.2018.1506884

Reference yield:

diisopropyl hydrogenphosphonate (1809-20-7) + benzaldehyde (100-52-7) → Toluene-4-sulfonic acid (diisopropoxy-phosphoryl)-phenyl-methyl ester (131523-50-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium methylate / diethyl ether / 20 °C

2: dmap; triethylamine / dichloromethane / 20 °C

With dmap; sodium methylate; triethylamine; In diethyl ether; dichloromethane;

DOI:10.1080/15257770.2018.1506884

Reference yield: 67.0%

Toluene-4-sulfonic acid (diisopropoxy-phosphoryl)-phenyl-methyl ester (131523-50-7) → O,O-diisopropyl-α-azidobenzylphosphonate (131523-52-9)

Guidance literature:

With sodium azide; In dimethyl sulfoxide; at 75 - 80 ℃;

upstream raw materials:

diisopropyl hydrogenphosphonate

benzaldehyde

(hydroxy-phenyl-methyl)-phosphonic acid diisopropyl ester

p-toluenesulfonyl chloride

Downstream raw materials:

O,O-diisopropyl-α-azidobenzylphosphonate