5-diethoxymethyl-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid ethyl ester

Base Information

• Chemical Name: 5-diethoxymethyl-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid ethyl ester
• CAS No.: 1222076-77-8
• Molecular Formula: C₁₇H₂₁FN₂O₄
• Molecular Weight: 336.363

Synonyms:5-diethoxymethyl-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid ethyl ester

Chemical Property of 5-diethoxymethyl-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid ethyl ester

Chemical Property:

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Technology Process of 5-diethoxymethyl-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid ethyl ester

There total 3 articles about 5-diethoxymethyl-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[1-dimethylamino-meth-(Z)-ylidene]-4,4-diethoxy-3-oxo-butyric acid ethyl ester (1300022-26-7) + 4-fluorophenyhydrazine hydrochloride (823-85-8) → 5-diethoxymethyl-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid ethyl ester (1222076-77-8)

Guidance literature:

In methanol; for 2h; Reflux;

Reference yield:

2-diethoxyacetyl-3-ethoxy-acrylic acid ethyl ester (40995-61-7) + 4-fluorophenylhydrazine (371-14-2) → 5-diethoxymethyl-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid ethyl ester (1222076-77-8)

Guidance literature:

In ethanol; at 0 - 20 ℃;

DOI:10.1016/j.bmcl.2010.01.059

Reference yield:

ethyl 4,4-diethoxyacetoacetate (10495-09-7) → 5-diethoxymethyl-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid ethyl ester (1222076-77-8)

Guidance literature:

Multi-step reaction with 2 steps

1: xylenes / 0.5 h / Reflux

2: methanol / 2 h / Reflux

In methanol; xylenes;

upstream raw materials:

2-diethoxyacetyl-3-ethoxy-acrylic acid ethyl ester

4-fluorophenylhydrazine

2-[1-dimethylamino-meth-(Z)-ylidene]-4,4-diethoxy-3-oxo-butyric acid ethyl ester

4-fluorophenyhydrazine hydrochloride

Downstream raw materials:

C₁₁H₇FN₄O

1-(4-fluorophenyl)-1H-pyrazolo[3,4-d]pyridazin-4-ol

4-chloro-1-(4-fluorophenyl)-1H-pyrazolo[3,4-d]pyridazine

1-(4-fluorophenyl)-1H-pyrazolo[3,4-d]pyridazine-4-carboxylic acid ethyl ester

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