10495-09-7

Basic information

• Product Name: ethyl 4,4-diethoxy-3-oxobutanoate
• Synonyms: ethyl 4,4-diethoxy-3-oxobutanoate;Butanoic acid, 4,4-diethoxy-3-oxo-, ethyl ester;4,4-Diethoxy-3-oxo-butyricacidethylester;Ethyl 4,4-bis(ethyloxy)-3-oxobutanoate
• CAS NO: 10495-09-7
• Molecular Formula: C₁₀H₁₈O₅
• Molecular Weight: 218.24692
• Mol File: 10495-09-7.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 112 °C(Press: 4-6 Torr)
• Appearance: /
• Density: 1.052±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 9.58±0.46(Predicted)
• CAS DataBase Reference: ethyl 4,4-diethoxy-3-oxobutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4,4-diethoxy-3-oxobutanoate(10495-09-7)
• EPA Substance Registry System: ethyl 4,4-diethoxy-3-oxobutanoate(10495-09-7)

Safety Data

• Hazardous Substances Data: 10495-09-7(Hazardous Substances Data)

Usage

General Description

Ethyl 4,4-diethoxy-3-oxobutanoate is a chemical compound with the molecular formula C11H20O5. It is also known as ethyl acetoacetate and is commonly used as a flavoring agent and fragrance ingredient in the food and cosmetic industry. It is a colorless liquid with a fruity odor and is soluble in alcohol and ether. Ethyl 4,4-diethoxy-3-oxobutanoate is also used as a precursor in the synthesis of various pharmaceuticals and agrochemicals. It is considered relatively safe when handled properly, but it can be harmful if ingested or inhaled in large quantities.

Upstream product

• 141-78-6 ethyl acetate 
• 6065-82-3 Ethyl diethoxyacetate 

Downstream Products

• 78711-26-9 2-amino-6-diethoxymethyl-3H-pyrimidin-4-one 
• 16953-49-4 6-diethoxymethyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one 
• 861584-19-2 6-diethoxymethyl-2-phenyl-3H-pyrimidin-4-one 
• 24132-51-2 ethyl 4,4-diethoxy-2-methyl-3-oxobutanoate 
• 19076-56-3 ethyl 2-formylfuran-3-carboxylate 

Relevant articles and documents

The disubstitution of acetals to prepare δ,δ-Bis(aryl) β-keto esters

An efficient catalytic protocol for the synthesis of δ,δ- bis(aryl)-substituted β-keto esters has been developed. This method involves the Lewis acid catalysed disubstitution reaction of ester-substituted silyl enol ether acetals with a series of aromatic

AZOLE-FUSED PYRIDAZIN-3(2H)-ONE DERIVATIVES

Disclosed are compounds of Formula (1) and pharmaceutically acceptable salts thereof, wherein α, β, n, R4, R5, R6, R8, R9, R10, R11, X1, X2, X3 and X7 are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula (1), to pharmaceutical compositions comprising them, and to their use for treating diseases, disorders, and conditions associated with GPR139.

PYRIMIDINE DERIVATIVES USED AS ITK INHIBITORS

The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular ltk activity.