<(1R,2S,3R,4S)-3-(2,2-dimethylpropoxy)-1,7,7-trimethylbicyclo<2.2.1>hept-2-yl>phenylpropiolate

Base Information

• Chemical Name: <(1R,2S,3R,4S)-3-(2,2-dimethylpropoxy)-1,7,7-trimethylbicyclo<2.2.1>hept-2-yl>phenylpropiolate
• CAS No.: 169136-75-8
• Molecular Formula: C₂₄H₃₂O₃
• Molecular Weight: 368.516
• Mol file: 169136-75-8.mol

Synonyms:<(1R,2S,3R,4S)-3-(2,2-dimethylpropoxy)-1,7,7-trimethylbicyclo<2.2.1>hept-2-yl>phenylpropiolate

Chemical Property of <(1R,2S,3R,4S)-3-(2,2-dimethylpropoxy)-1,7,7-trimethylbicyclo<2.2.1>hept-2-yl>phenylpropiolate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of <(1R,2S,3R,4S)-3-(2,2-dimethylpropoxy)-1,7,7-trimethylbicyclo<2.2.1>hept-2-yl>phenylpropiolate

There total 1 articles about <(1R,2S,3R,4S)-3-(2,2-dimethylpropoxy)-1,7,7-trimethylbicyclo<2.2.1>hept-2-yl>phenylpropiolate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

phenylpropiolyl chloride (7299-58-3) + (1R,2S,3R,4S)-3-(2,2-dimethylpropoxy)-1,7,7-trimethylbicyclo<2.2.1>heptan-2-ol (85695-92-7) → <(1R,2S,3R,4S)-3-(2,2-dimethylpropoxy)-1,7,7-trimethylbicyclo<2.2.1>hept-2-yl>phenylpropiolate (169136-75-8)

Guidance literature:

With silver cyanide; In benzene; Heating;

DOI:10.1016/0040-4020(95)00152-X

Reference yield:

norborn-2-ene (498-66-8) + <(1R,2S,3R,4S)-3-(2,2-dimethylpropoxy)-1,7,7-trimethylbicyclo<2.2.1>hept-2-yl>phenylpropiolate (169136-75-8) → (3aS,4R,7S,7aR)-3-Oxo-2-phenyl-3a,4,5,6,7,7a-hexahydro-3H-4,7-methano-indene-1-carboxylic acid (1R,2S,3R,4S)-3-(2,2-dimethyl-propoxy)-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester + (1R*,2S*,6R*,7S*)-5-oxo-4-phenyltricyclo<5.2.1.02,6>dec-3-ene-3-carboxylic acid (1R,2S,3R,4S)-3-(2,2-dimethylpropoxy)-1,7,7-trimethylbicyclo<2.2.1>hept-2-yl ester,

Guidance literature:

With dicobalt octacarbonyl; In toluene; at 60 ℃; for 10h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1016/0040-4020(95)00152-X

Reference yield:

bicyclo[2.2.1]hepta-2,5-diene (121-46-0) + <(1R,2S,3R,4S)-3-(2,2-dimethylpropoxy)-1,7,7-trimethylbicyclo<2.2.1>hept-2-yl>phenylpropiolate (169136-75-8) → (3aS,4S,7R,7aR)-3-Oxo-2-phenyl-3a,4,7,7a-tetrahydro-3H-4,7-methano-indene-1-carboxylic acid (1R,2S,3R,4S)-3-(2,2-dimethyl-propoxy)-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester + (1R*,2R*,6S*,7S*)-5-oxo-4-phenyltricyclo<5.2.1.02,6>deca-3,8-diene-3-carboxylic acid (1R,2S,3R,4S)-3-(2,2-dimethylpropoxy)-1,7,7-trimethylbicyclo<2.2.1>hept-2-yl ester

Guidance literature:

With dicobalt octacarbonyl; In toluene; at 40 ℃; for 30h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1016/0040-4020(95)00152-X

upstream raw materials:

phenylpropiolyl chloride

(1R,2S,3R,4S)-3-(2,2-dimethylpropoxy)-1,7,7-trimethylbicyclo<2.2.1>heptan-2-ol