7299-58-3

Basic information

• Product Name: 2-PROPYNOYL CHLORIDE,3-PHENYL-
• Synonyms: 2-PROPYNOYL CHLORIDE,3-PHENYL-
• CAS NO: 7299-58-3
• Molecular Formula: C₉H₅ClO
• Molecular Weight: 164.59
• Mol File: 7299-58-3.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-PROPYNOYL CHLORIDE,3-PHENYL-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PROPYNOYL CHLORIDE,3-PHENYL-(7299-58-3)
• EPA Substance Registry System: 2-PROPYNOYL CHLORIDE,3-PHENYL-(7299-58-3)

Safety Data

• Hazardous Substances Data: 7299-58-3(Hazardous Substances Data)

Upstream product

• 7719-09-7 thionyl chloride 
• 637-44-5 phenylpropyolic acid 
• 10026-13-8 phosphorus pentachloride 
• 6286-30-2 2,3-dibromo-3-phenylpropanoic acid 
• 621-82-9 Cinnamic acid 
• 591-50-4 iodobenzene 
• 71-43-2 benzene 
• 2216-94-6 phenylpropynoic acid ethyl ester 
• 79023-44-2 3,3,3-triethoxy-1-phenyl-1-propyne 
• 536-74-3 phenylacetylene 
• 7063-23-2 phenylpropiolic acid sodium salt 

Downstream Products

• 50428-40-5 Tris(phenylethynyl)methyl alcohol 
• 101895-82-3 phenyl-propiolic acid-(4-amino-2-methyl-[6]quinolylamide) 
• 950-91-4 3-phenyl-2,5-norbornadiene-2-carboxylic acid 
• 16616-43-6 1-(4-methoxy-phenyl)-3-phenyl-propynone 
• 7342-02-1 3-phenylpropynoic acid phenylamide 
• 1985-37-1 4-phenylnaphtho[2,3-c]furan-1,3-dione 
• 91827-36-0 N-(2-Chloroethyl)-1-phenylnaphthalene-2,3-dicarboximide 
• 169136-75-8 <(1R,2S,3R,4S)-3-(2,2-dimethylpropoxy)-1,7,7-trimethylbicyclo<2.2.1>hept-2-yl>phenylpropiolate 
• 169136-79-2 <(1R,2S,4S)-1,7,7-trimethylspiro(bicyclo<2.2.1>heptan-3,2'-indan)-2-yl> phenylpropiolate 
• 95969-89-4 1-(morpholin-4-yl)-3-phenylprop-2-yn-1-one 
• 110381-04-9 1-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-3-phenyl-propynone 
• 343617-25-4 3-Phenyl-propynoic acid (3-trifluoromethyl-phenyl)-amide 
• 208335-77-7 N-phenethyl-3-phenylpropiolamide 
• 332044-39-0 N-(4-nitrophenyl)-3-phenylpropiolamide 

Relevant articles and documents

Carbene-catalyzed LUMO activation of alkyne esters for access to functional pyridines

A carbene-catalyzed LUMO activation of α,β-unsaturated alkyne esters is reported. This catalytic process allows for effective reactions of alkyne esters with enamides to synthesize functional pyridines via simple protocols. A previously unexplored unsaturated alkyne acyl azolium intermediate is involved in the key step of the reaction.

Synthesis of 1,4-diphenylbutadiene derivatives: Novel inducer of tissue-type plasminogen activator (t-PA) in cultured bovine endothelial cells

(E,E)-1,4-Diphenylbutadiene derivatives were synthesized by utilizing the Stobbe reaction of dimethyl succinate as a key step. Their stereoisomers were also synthesized stereoselectively by means of the cross-coupling reaction of the vinylstannanes and the vinylbromides, which were obtained from the propiolic acid esters by stereoselective hydrostannation, as a key step. To discover novel stimulators of fibrinolysis in vascular endothelial cells, the synthesized compounds were added to cultured bovine endothelial cells to determine the activity of the plasminogen activator in the conditioned medium. Of the synthesized compounds, three compounds were found to stimulate the activity of the plasminogen activator in endothelial cells. In addtition, these compounds inhibited thrombus formation in a rat model of venous thrombosis.

Flash Vacuum Pyrolysis of Stabilised Phosphorous Ylides. Part 4. Stepwise Construction of Terminal 1,3-Diynes, Conjugated Diacetylenic Esters and a Triacetylenic Ester

Thirteen examples of stabilised alkynol ylides 6 have been prepared and are found, upon flash vacuum pyrolysis (FVP) at 500 deg C, to undergo extrusion of Ph3PO to give the diacetylenic esters 7 in moderate yield.At 750 deg C the same ylides afforded terminal 1,3-diynes 8 although often in poor yield.For R = 2-MeSC6H4 both 7 and 8 undergo secondary loss of Me* and cyclisation to give 2-alkynylbenzothiophene derivatives 9 and 10 in low yield.The first example of an alkadiynol ylide 11 has been prepared and is converted by FVP at 500 deg C into the triacetylenic ester 12.