N-(benzo[1,3]dioxol-5-ylmethyl)-N-[2-(2-methoxy-6-methoxymethoxyphenyl)ethyl]-4-methylbenzenesulfonamide

Base Information

Chemical Name:N-(benzo[1,3]dioxol-5-ylmethyl)-N-[2-(2-methoxy-6-methoxymethoxyphenyl)ethyl]-4-methylbenzenesulfonamide
CAS No.:849915-10-2
Molecular Formula:C₂₆H₂₉NO₇S
Molecular Weight:499.585
Hs Code.:

Synonyms:N-(benzo[1,3]dioxol-5-ylmethyl)-N-[2-(2-methoxy-6-methoxymethoxyphenyl)ethyl]-4-methylbenzenesulfonamide

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Chemical Property of N-(benzo[1,3]dioxol-5-ylmethyl)-N-[2-(2-methoxy-6-methoxymethoxyphenyl)ethyl]-4-methylbenzenesulfonamide

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Technology Process of N-(benzo[1,3]dioxol-5-ylmethyl)-N-[2-(2-methoxy-6-methoxymethoxyphenyl)ethyl]-4-methylbenzenesulfonamide

There total 5 articles about N-(benzo[1,3]dioxol-5-ylmethyl)-N-[2-(2-methoxy-6-methoxymethoxyphenyl)ethyl]-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 849915-09-9
N-(benzo[1,3]dioxol-5-ylmethyl)-N-[2-(2-methoxy-6-methoxymethoxyphenyl)ethyl]amine

: 98-59-9
p-toluenesulfonyl chloride

: 849915-10-2
N-(benzo[1,3]dioxol-5-ylmethyl)-N-[2-(2-methoxy-6-methoxymethoxyphenyl)ethyl]-4-methylbenzenesulfonamide

Guidance literature:: With pyridine; In dichloromethane; at 0 ℃; for 12h;
DOI:10.1021/ol047520+

Reference yield:

: 57234-28-3
1-methoxy-3-(methoxymethoxy)benzene

: 849915-10-2
N-(benzo[1,3]dioxol-5-ylmethyl)-N-[2-(2-methoxy-6-methoxymethoxyphenyl)ethyl]-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-BuLi / diethyl ether; hexane / 1.5 h / 20 °C

1.2: 73 percent / diethyl ether; hexane / 0.5 h / 20 °C

2.1: O₃ / CH₂Cl₂; methanol / -78 °C

2.2: 86 percent / Me₂S / CH₂Cl₂; methanol / -78 - 20 °C

3.1: 73 percent / NaBH₄; AcOH / methanol / 0.5 h / 20 °C / pH 4 - 5

4.1: 67 percent / pyridine / CH₂Cl₂ / 12 h / 0 °C

With pyridine; sodium tetrahydroborate; n-butyllithium; ozone; acetic acid; In methanol; diethyl ether; hexane; dichloromethane;
DOI:10.1021/ol047520+

Reference yield:

: 849915-08-8
(2-methoxy-6-methoxymethoxyphenyl)acetaldehyde

: 849915-10-2
N-(benzo[1,3]dioxol-5-ylmethyl)-N-[2-(2-methoxy-6-methoxymethoxyphenyl)ethyl]-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / NaBH₄; AcOH / methanol / 0.5 h / 20 °C / pH 4 - 5

2: 67 percent / pyridine / CH₂Cl₂ / 12 h / 0 °C

With pyridine; sodium tetrahydroborate; acetic acid; In methanol; dichloromethane;
DOI:10.1021/ol047520+