methyl 2-(2-(3-cyclopropoxyphenyl)pyrimidin-5-ylamino)-5-cyclopropylbenzoate

Base Information

Chemical Name:methyl 2-(2-(3-cyclopropoxyphenyl)pyrimidin-5-ylamino)-5-cyclopropylbenzoate
CAS No.:1119090-55-9
Molecular Formula:C₂₄H₂₃N₃O₃
Molecular Weight:401.465
Hs Code.:

Synonyms:methyl 2-(2-(3-cyclopropoxyphenyl)pyrimidin-5-ylamino)-5-cyclopropylbenzoate

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Chemical Property of methyl 2-(2-(3-cyclopropoxyphenyl)pyrimidin-5-ylamino)-5-cyclopropylbenzoate

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Technology Process of methyl 2-(2-(3-cyclopropoxyphenyl)pyrimidin-5-ylamino)-5-cyclopropylbenzoate

There total 5 articles about methyl 2-(2-(3-cyclopropoxyphenyl)pyrimidin-5-ylamino)-5-cyclopropylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 808140-97-8
(3-cyclopropoxyphenyl)boronic acid

: 1119088-94-6
methyl 2-(2-chloropyrimidin-5-ylamino)-5-cyclopropylbenzoate

: 1119090-55-9
methyl 2-(2-(3-cyclopropoxyphenyl)pyrimidin-5-ylamino)-5-cyclopropylbenzoate

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 110 ℃; for 12h;

Reference yield:

: 1035690-22-2
1-bromo-3-(cyclopropyloxy)benzene

: 1119090-55-9
methyl 2-(2-(3-cyclopropoxyphenyl)pyrimidin-5-ylamino)-5-cyclopropylbenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium acetate; bis(pinacol)diborane / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 0.75 h / 130 °C / Microwave irradiation

2: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 12 h / 110 °C

With potassium acetate; potassium carbonate; bis(pinacol)diborane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; dimethyl sulfoxide;

Reference yield:

: 591-20-8
3-Bromophenol

: 1119090-55-9
methyl 2-(2-(3-cyclopropoxyphenyl)pyrimidin-5-ylamino)-5-cyclopropylbenzoate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 180 °C / Microwave irradiation

2: potassium acetate; bis(pinacol)diborane / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 0.75 h / 130 °C / Microwave irradiation

3: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 12 h / 110 °C

With potassium acetate; potassium carbonate; bis(pinacol)diborane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;