(S)-4-(Benzenesulfonyl-methyl-amino)-4-{(S)-2-[4-(2,6-dichloro-benzyloxy)-phenyl]-1-methoxycarbonyl-ethylcarbamoyl}-butyric acid tert-butyl ester

Base Information

Chemical Name:(S)-4-(Benzenesulfonyl-methyl-amino)-4-{(S)-2-[4-(2,6-dichloro-benzyloxy)-phenyl]-1-methoxycarbonyl-ethylcarbamoyl}-butyric acid tert-butyl ester
CAS No.:628724-20-9
Molecular Formula:C₃₃H₃₈Cl₂N₂O₈S
Molecular Weight:693.645
Hs Code.:

Synonyms:(S)-4-(Benzenesulfonyl-methyl-amino)-4-{(S)-2-[4-(2,6-dichloro-benzyloxy)-phenyl]-1-methoxycarbonyl-ethylcarbamoyl}-butyric acid tert-butyl ester

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Chemical Property of (S)-4-(Benzenesulfonyl-methyl-amino)-4-{(S)-2-[4-(2,6-dichloro-benzyloxy)-phenyl]-1-methoxycarbonyl-ethylcarbamoyl}-butyric acid tert-butyl ester

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Technology Process of (S)-4-(Benzenesulfonyl-methyl-amino)-4-{(S)-2-[4-(2,6-dichloro-benzyloxy)-phenyl]-1-methoxycarbonyl-ethylcarbamoyl}-butyric acid tert-butyl ester

There total 2 articles about (S)-4-(Benzenesulfonyl-methyl-amino)-4-{(S)-2-[4-(2,6-dichloro-benzyloxy)-phenyl]-1-methoxycarbonyl-ethylcarbamoyl}-butyric acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 98-09-9
benzenesulfonyl chloride

: 628724-19-6
4-{2-[4-(2,6-dichloro-benzyloxy)-phenyl]-1-methoxycarbonyl-ethylcarbamoyl}-4-[(9H-fluoren-9-ylmethoxycarbonyl)-methyl-amino]-butyric acid tert-butyl ester

: 628724-20-9
(S)-4-(Benzenesulfonyl-methyl-amino)-4-{(S)-2-[4-(2,6-dichloro-benzyloxy)-phenyl]-1-methoxycarbonyl-ethylcarbamoyl}-butyric acid tert-butyl ester

Guidance literature:: 4-{2-[4-(2,6-dichloro-benzyloxy)-phenyl]-1-methoxycarbonyl-ethylcarbamoyl}-4-[(9H-fluoren-9-ylmethoxycarbonyl)-methyl-amino]-butyric acid tert-butyl ester; With diethylamine; In dichloromethane;

benzenesulfonyl chloride; With 4-methyl-morpholine; In dichloromethane;
DOI:10.1016/S0960-894X(03)00760-1

Reference yield:

: (S)-O-(2,6-dichlorobenzyl)tyrosine methyl ester

: 628724-20-9
(S)-4-(Benzenesulfonyl-methyl-amino)-4-{(S)-2-[4-(2,6-dichloro-benzyloxy)-phenyl]-1-methoxycarbonyl-ethylcarbamoyl}-butyric acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 93 percent / TBTU; DIEA / CH₂Cl₂

2.1: Et₂NH / CH₂Cl₂

2.2: 72 percent / NMM / CH₂Cl₂

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; diethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1016/S0960-894X(03)00760-1

Reference yield: 86.0%

: 628724-20-9
(S)-4-(Benzenesulfonyl-methyl-amino)-4-{(S)-2-[4-(2,6-dichloro-benzyloxy)-phenyl]-1-methoxycarbonyl-ethylcarbamoyl}-butyric acid tert-butyl ester

: (S)-4-(Benzenesulfonyl-methyl-amino)-4-{(S)-1-carboxy-2-[4-(2,6-dichloro-benzyloxy)-phenyl]-ethylcarbamoyl}-butyric acid

Guidance literature:: (S)-4-(Benzenesulfonyl-methyl-amino)-4-{(S)-2-[4-(2,6-dichloro-benzyloxy)-phenyl]-1-methoxycarbonyl-ethylcarbamoyl}-butyric acid tert-butyl ester; With lithium hydroxide; In tetrahydrofuran; for 2h;

With trifluoroacetic acid;
DOI:10.1016/S0960-894X(03)00760-1