tert-butyl N-((3R)-3-{[tert-butyl(dimethyl)silyl]oxy}butoxycarbonyl)-3-({[(5R)-3-(4-cyanophenyl)-4,5-dihydro-5-isoxazolyl]acetyl}amino)-L-alaninate

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Chemical Name:tert-butyl N-((3R)-3-{[tert-butyl(dimethyl)silyl]oxy}butoxycarbonyl)-3-({[(5R)-3-(4-cyanophenyl)-4,5-dihydro-5-isoxazolyl]acetyl}amino)-L-alaninate
CAS No.:752235-85-1
Molecular Formula:C₃₀H₄₆N₄O₇Si
Molecular Weight:602.803
Hs Code.:

Synonyms:tert-butyl N-((3R)-3-{[tert-butyl(dimethyl)silyl]oxy}butoxycarbonyl)-3-({[(5R)-3-(4-cyanophenyl)-4,5-dihydro-5-isoxazolyl]acetyl}amino)-L-alaninate

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Chemical Property of tert-butyl N-((3R)-3-{[tert-butyl(dimethyl)silyl]oxy}butoxycarbonyl)-3-({[(5R)-3-(4-cyanophenyl)-4,5-dihydro-5-isoxazolyl]acetyl}amino)-L-alaninate

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Technology Process of tert-butyl N-((3R)-3-{[tert-butyl(dimethyl)silyl]oxy}butoxycarbonyl)-3-({[(5R)-3-(4-cyanophenyl)-4,5-dihydro-5-isoxazolyl]acetyl}amino)-L-alaninate

There total 5 articles about tert-butyl N-((3R)-3-{[tert-butyl(dimethyl)silyl]oxy}butoxycarbonyl)-3-({[(5R)-3-(4-cyanophenyl)-4,5-dihydro-5-isoxazolyl]acetyl}amino)-L-alaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 752235-84-0
(3R)-3-tert-butyl(dimethyl)silyloxybutyl chlorocarbonate

: 752235-76-0
tert-butyl 3-({[(5R)-3-(4-cyanophenyl)-4,5-dihydro-5-isoxazolyl]acetyl}amino)-L-alaninate

: 752235-85-1
tert-butyl N-((3R)-3-{[tert-butyl(dimethyl)silyl]oxy}butoxycarbonyl)-3-({[(5R)-3-(4-cyanophenyl)-4,5-dihydro-5-isoxazolyl]acetyl}amino)-L-alaninate

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 1.5h;
DOI:10.3987/COM-04-10087

Reference yield:

: 77215-55-5
tert-butyl 2-N-carbobenzoxy-(S)-2,3-diaminopropionate

: 752235-85-1
tert-butyl N-((3R)-3-{[tert-butyl(dimethyl)silyl]oxy}butoxycarbonyl)-3-({[(5R)-3-(4-cyanophenyl)-4,5-dihydro-5-isoxazolyl]acetyl}amino)-L-alaninate

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / TBTU; Et₃N / dimethylformamide / 5 h / 20 °C

2: 55 percent / 1,4-cyclohexadiene / Pd(OH)2 / methanol / 6 h / Heating

3: 74 percent / Et₃N / tetrahydrofuran / 1.5 h / 20 °C

With cyclohexa-1,4-diene; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; palladium dihydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.3987/COM-04-10087

Reference yield:

: 181023-08-5
(R)-2-[3-(4-cyanophenyl)-4,5-dihydroisoxazol-5-yl]acetic acid

: 752235-85-1
tert-butyl N-((3R)-3-{[tert-butyl(dimethyl)silyl]oxy}butoxycarbonyl)-3-({[(5R)-3-(4-cyanophenyl)-4,5-dihydro-5-isoxazolyl]acetyl}amino)-L-alaninate

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / TBTU; Et₃N / dimethylformamide / 5 h / 20 °C

2: 55 percent / 1,4-cyclohexadiene / Pd(OH)2 / methanol / 6 h / Heating

3: 74 percent / Et₃N / tetrahydrofuran / 1.5 h / 20 °C

With cyclohexa-1,4-diene; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; palladium dihydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.3987/COM-04-10087