8-Methyl-2-(trifluoromethyl)quinoline

Base Information

Chemical Name:8-Methyl-2-(trifluoromethyl)quinoline
CAS No.:1860-46-4
Molecular Formula:C₁₁H₈F₃N
Molecular Weight:211.186
Hs Code.:2933499090
DSSTox Substance ID:DTXSID30589611
Nikkaji Number:J2.244.582K
Wikidata:Q82483078
Mol file:1860-46-4.mol

Synonyms:8-Methyl-2-(trifluoromethyl)quinoline;1860-46-4;8-Methyl-2-trifluoromethylquinoline;SCHEMBL8325687;DTXSID30589611;QLTYGFJHXYCNMR-UHFFFAOYSA-N;SB70465;DB-264202

Suppliers and Price of 8-Methyl-2-(trifluoromethyl)quinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
8-METHYL-2-TRIFLUOROMETHYLQUINOLINE 95.00%
5MG
$ 498.37

Total 9 raw suppliers

Chemical Property of 8-Methyl-2-(trifluoromethyl)quinoline

Chemical Property:

Vapor Pressure:0.038mmHg at 25°C
Refractive Index:1.537
Boiling Point:248.686°C at 760 mmHg
Flash Point:104.202°C
PSA：12.89000
Density:1.268g/cm³
LogP:3.56200
XLogP3:3.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:0
Exact Mass:211.06088375
Heavy Atom Count:15
Complexity:226

Purity/Quality:

98%,99%, ^*data from raw suppliers

8-METHYL-2-TRIFLUOROMETHYLQUINOLINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C2C(=CC=C1)C=CC(=N2)C(F)(F)F

Technology Process of 8-Methyl-2-(trifluoromethyl)quinoline

There total 9 articles about 8-Methyl-2-(trifluoromethyl)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 127223-93-2
(E)-4-(dimethylamino)-1,1,1-trifluorobut-3-en-2-one

: 95-53-4
o-toluidine

: 1860-46-4
8-methyl-2-(trifluoromethyl)quinoline

Guidance literature:: With trifluoromethylsulfonic anhydride; In o-xylene; Heating;
DOI:10.1002/(SICI)1099-0690(199904)1999:4<937::AID-EJOC937>3.0.CO;2-3

Reference yield: 81.0%

: 1-iodo-3,3,4,4,4-pentafluorobutyl acetate

: 95-53-4
o-toluidine

: 1860-46-4
8-methyl-2-(trifluoromethyl)quinoline

Guidance literature:: In dichloromethane; for 12h; Heating;
DOI:10.1021/jo050586d

Reference yield: 56.0%

: 611-32-5
8-methylquinoline

: 81290-20-2
(trifluoromethyl)trimethylsilane

: 1860-46-4
8-methyl-2-(trifluoromethyl)quinoline

Guidance literature:: 8-methylquinoline; With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; potassium hydrogen difluoride; In 1,4-dioxane; at 25 ℃; for 0.00833333h;

(trifluoromethyl)trimethylsilane; With trifluoroacetic acid; In 1,4-dioxane; at 25 ℃; for 24h;

With [bis(acetoxy)iodo]benzene; In 1,4-dioxane; at 25 ℃; for 2h;
DOI:10.1021/acs.orglett.8b00339