PYRIDIN-4-YL-METHANETHIOL

Base Information

• Chemical Name: PYRIDIN-4-YL-METHANETHIOL
• CAS No.: 1822-53-3
• Molecular Formula: C6H7 N S
• Molecular Weight: 125.194
• Hs Code.: 2933399090
• Mol file: 1822-53-3.mol

Synonyms:(4-Pyridyl)methylthiol;4-(Mercaptomethyl)pyridine; 4-Pyridylmethyl mercaptan; Pyridin-4-ylmethanethiol

Chemical Property of PYRIDIN-4-YL-METHANETHIOL

Chemical Property:

• Boiling Point: 109-111 °C(Press: 8 Torr)
• PKA: 8.25±0.10(Predicted)
• PSA: 51.69000
• Density: 1.107±0.06 g/cm3(Predicted)
• LogP: 1.51140

Purity/Quality:

98%Min ^*data from raw suppliers

pyridin-4-ylmethanethiol 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of PYRIDIN-4-YL-METHANETHIOL

There total 1 articles about PYRIDIN-4-YL-METHANETHIOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

pyridine-4-carbothioamide (2196-13-6) → 4-(aminomethyl)pyridine (3731-53-1) + pyridin-4-ylmethanethiol (1822-53-3)

Guidance literature:

With sulfuric acid; at 25 ℃; Mechanism; also with thionicotinamide; var. pH's; electrochemical reduction;

Reference yield: 88.0%

pyridin-4-ylmethanethiol (1822-53-3) + 3-chloromethyl-7β-tert-butyloxycarbonylamino-3-cephem-4-carboxylic acid diphenylmethyl ester (112028-91-8) → diphenylmethyl 7β-tert-butoxycarbonylamino-3-(4-pyridyl)methylthiomethyl-3-cephem-4-carboxylate (288379-40-8)

Guidance literature:

3-chloromethyl-7β-tert-butyloxycarbonylamino-3-cephem-4-carboxylic acid diphenylmethyl ester; With sodium iodide; In N,N-dimethyl-formamide; at 20 ℃;

pyridin-4-ylmethanethiol; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

DOI:10.1016/S0968-0896(00)00021-3

Reference yield: 88.0%

pyridin-4-ylmethanethiol (1822-53-3) + diphenylmethyl 7β-formamido-3-methanesulfonyloxy-3-cephem-4-carboxylate → diphenylmethyl 7β-formamido-3-[(4-pyridyl)methylthio]-3-cephem-4-carboxylate (103544-80-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at -20 ℃; for 1.9h;

DOI:10.1016/S0968-0896(00)00021-3

upstream raw materials:

pyridine-4-carbothioamide

Downstream raw materials:

diphenylmethyl 7β-tert-butoxycarbonylamino-3-(4-pyridyl)methylthiomethyl-3-cephem-4-carboxylate

diphenylmethyl 7β-formamido-3-[(4-pyridyl)methylthio]-3-cephem-4-carboxylate

diphenylmethyl 7β-tert-butoxycarbonylamino-3-[(E)-2-(4-pyridyl)methylthiovinyl]-3-cephem-4-carboxylate

{(1S,2R)-1-Benzyl-3-[(2S,4R)-2-tert-butylcarbamoyl-4-(pyridin-4-ylmethylsulfanyl)-piperidin-1-yl]-2-hydroxy-propyl}-carbamic acid tert-butyl ester

Refernces