3-(Piperidin-3-yl)propanoic acid

Base Information

• Chemical Name: 3-(Piperidin-3-yl)propanoic acid
• CAS No.: 1822-31-7
• Molecular Formula: C8H15NO2
• Molecular Weight: 157.21
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID00408901
• Mol file: 1822-31-7.mol

Synonyms:3-(piperidin-3-yl)propanoic acid;1822-31-7;3-Piperidinepropanoic acid;3-piperidin-3-ylpropanoic acid;3-Piperidin-3-yl-propionic acid;3-Piperidinepropanoicacid;3-(3-piperidinyl)propanoic acid;3-piperidinepropionic acid;SCHEMBL2525645;3-(piperidin-3-yl)propanoicacid;DTXSID00408901;FCDZOPQSMGHRMK-UHFFFAOYSA-N;AKOS005604476;SB41822;AM100414;3-piperidin-3-yl-propionic acid, AldrichCPR;A4032;BB 0258320;CS-0271296;EN300-56238;F8880-4350

Chemical Property of 3-(Piperidin-3-yl)propanoic acid

Chemical Property:

• Vapor Pressure: 0.000284mmHg at 25°C
• Refractive Index: 1.466
• Boiling Point: 299.4 °C at 760 mmHg
• Flash Point: 134.9 °C
• PSA: 49.33000
• Density: 1.039 g/cm³
• LogP: 1.17960
• Storage Temp.: 2-8°C
• XLogP3: -1.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 157.110278721
• Heavy Atom Count: 11
• Complexity: 136

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Piperidin-3-ylpropanoic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(CNC1)CCC(=O)O
• Uses: 3-(3-Piperidinyl)propanoic Acid (cas# 1822-31-7) is a useful reagent for synthesizing Truxillic Acid derivatives to study the allosteric binding site of muscarinic acetylcholine receptors.

Technology Process of 3-(Piperidin-3-yl)propanoic acid

There total 4 articles about 3-(Piperidin-3-yl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3-(pyridin-3-yl)acrylic acid (1126-74-5) → 3-(piperidin-3-yl)propionic acid (1822-31-7)

Guidance literature:

3-(pyridin-3-yl)acrylic acid; With hydrogenchloride; In 1,4-dioxane; water; at 25 ℃; for 0.5h;

With platinum(IV) oxide; hydrogen; acetic acid; at 25 ℃; for 12h; under 2585.81 Torr;

Reference yield:

→ 3-(piperidin-3-yl)propionic acid (1822-31-7)

Guidance literature:

With hydrogenchloride;

Reference yield:

trans-3-(3-pyridyl)acrylic acid (19337-97-4,1126-74-5) → 3-(piperidin-3-yl)propionic acid (1822-31-7)

Guidance literature:

With water; platinum; Hydrogenation;

upstream raw materials:

trans-3-(3-pyridyl)acrylic acid

3-(pyridin-3-yl)acrylic acid

Downstream raw materials:

1-Azabicyclo<3.3.1>nonan-2-one

N-(3,5-dimethoxyphenyl)-3-(1-(4-fluoro-3-methoxybenzyl)piperidin-3-yl)propanamide

Refernces

• 1、 -. "COMPOUNDS, COMPOSITIONS AND METHODS OF USE AGAINST STRESS GRANULES". Paragraph 0321-0323. . Retrieved 2018/11/21.