(-)-benzyl (2R,4S,6R)-4-(acetyloxy)-2-methyl-6-vinylpiperidine-1-carboxylate

Base Information

• Chemical Name: (-)-benzyl (2R,4S,6R)-4-(acetyloxy)-2-methyl-6-vinylpiperidine-1-carboxylate
• CAS No.: 1146061-47-3
• Molecular Formula: C₁₈H₂₃NO₄
• Molecular Weight: 317.385
• Mol file: 1146061-47-3.mol

Synonyms:(-)-benzyl (2R,4S,6R)-4-(acetyloxy)-2-methyl-6-vinylpiperidine-1-carboxylate

Chemical Property of (-)-benzyl (2R,4S,6R)-4-(acetyloxy)-2-methyl-6-vinylpiperidine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (-)-benzyl (2R,4S,6R)-4-(acetyloxy)-2-methyl-6-vinylpiperidine-1-carboxylate

There total 1 articles about (-)-benzyl (2R,4S,6R)-4-(acetyloxy)-2-methyl-6-vinylpiperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(-)-benzyl (2R,4S,6R)-4-hydroxy-2-methyl-6-vinylpiperidine-1-carboxylate (1198807-42-9) + acetic anhydride (108-24-7) → (-)-benzyl (2R,4S,6R)-4-(acetyloxy)-2-methyl-6-vinylpiperidine-1-carboxylate (1146061-47-3)

Guidance literature:

With pyridine; at 20 ℃; for 19h;

DOI:10.1002/chem.200901316

Reference yield: 93.0%

(-)-benzyl (2R,4S,6R)-4-(acetyloxy)-2-methyl-6-vinylpiperidine-1-carboxylate (1146061-47-3) → (+)-benzyl (2R,4S,6R)-4-(acetyloxy)-2-formyl-6-methylpiperidine-1-carboxylate (1146061-54-2)

Guidance literature:

With dimethylsulfide; ozone; In methanol; dichloromethane; at -78 ℃;

DOI:10.1002/chem.200802525

Reference yield: 71.0%

non-1-ene (124-11-8) + (-)-benzyl (2R,4S,6R)-4-(acetyloxy)-2-methyl-6-vinylpiperidine-1-carboxylate (1146061-47-3) → C25H37NO4 (1146061-63-3)

Guidance literature:

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; for 5h; Reflux;

DOI:10.1002/chem.200802525

upstream raw materials:

(-)-benzyl (2R,4S,6R)-4-hydroxy-2-methyl-6-vinylpiperidine-1-carboxylate

acetic anhydride

Downstream raw materials:

(+)-benzyl (2R,4S,6R)-4-(acetyloxy)-2-formyl-6-methylpiperidine-1-carboxylate

C₂₅H₃₇NO₄

(-)-benzyl (2R,4S,6R)-4-(acetyloxy)-2-methyl-6-[(E)-non-1'-en-1'-yl]piperidine-1-carboxylate