6-(3,5-difluorophenyl)-2-[3-(5-methylthiazol-2-yl)-benzyl]-2H-pyridazine-3-thione

Base Information

Chemical Name:6-(3,5-difluorophenyl)-2-[3-(5-methylthiazol-2-yl)-benzyl]-2H-pyridazine-3-thione
CAS No.:1119204-80-6
Molecular Formula:C₂₁H₁₅F₂N₃S₂
Molecular Weight:411.499
Hs Code.:

Synonyms:6-(3,5-difluorophenyl)-2-[3-(5-methylthiazol-2-yl)-benzyl]-2H-pyridazine-3-thione

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Chemical Property of 6-(3,5-difluorophenyl)-2-[3-(5-methylthiazol-2-yl)-benzyl]-2H-pyridazine-3-thione

Chemical Property:

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Technology Process of 6-(3,5-difluorophenyl)-2-[3-(5-methylthiazol-2-yl)-benzyl]-2H-pyridazine-3-thione

There total 7 articles about 6-(3,5-difluorophenyl)-2-[3-(5-methylthiazol-2-yl)-benzyl]-2H-pyridazine-3-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1119204-93-1
3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]-N-prop-2-ynylbenzamide

: 1119204-80-6
6-(3,5-difluorophenyl)-2-[3-(5-methylthiazol-2-yl)-benzyl]-2H-pyridazine-3-thione

Guidance literature:: With tetraphosphorus decasulfide; In toluene; at 90 ℃; for 20h;

Reference yield:

: 156545-07-2
3,5-difluorophenylboronic acid

: 1119204-80-6
6-(3,5-difluorophenyl)-2-[3-(5-methylthiazol-2-yl)-benzyl]-2H-pyridazine-3-thione

Guidance literature:: Multi-step reaction with 6 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water / 5 h / 100 °C

2: water; formic acid / 18 h / Heating

3: caesium carbonate / N,N-dimethyl-formamide / 20 h / 20 °C

4: sodium hydroxide; water / methanol / 18 h / Reflux

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 18 h / 20 °C

6: tetraphosphorus decasulfide / toluene / 20 h / 90 °C

With formic acid; tetraphosphorus decasulfide; water; sodium carbonate; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; ethanol; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 123577-99-1
3′,5′-difluoroacetophenone

: 1119204-80-6
6-(3,5-difluorophenyl)-2-[3-(5-methylthiazol-2-yl)-benzyl]-2H-pyridazine-3-thione

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid / 18 h / 95 °C

1.2: 4 h / 30 - 95 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 20 h / 20 °C

3.1: sodium hydroxide; water / methanol / 18 h / Reflux

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 18 h / 20 °C

5.1: tetraphosphorus decasulfide / toluene / 20 h / 90 °C

With tetraphosphorus decasulfide; water; benzotriazol-1-ol; caesium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In methanol; N,N-dimethyl-formamide; toluene;