3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]-N-prop-2-ynylbenzamide

Base Information

Chemical Name:3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]-N-prop-2-ynylbenzamide
CAS No.:1119204-93-1
Molecular Formula:C₂₁H₁₅F₂N₃O₂
Molecular Weight:379.366
Hs Code.:

Synonyms:3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]-N-prop-2-ynylbenzamide

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Chemical Property of 3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]-N-prop-2-ynylbenzamide

Chemical Property:

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Technology Process of 3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]-N-prop-2-ynylbenzamide

There total 6 articles about 3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]-N-prop-2-ynylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1007099-00-4
3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]benzoic acid

: 2450-71-7
Propargylamine

: 1119204-93-1
3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]-N-prop-2-ynylbenzamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

: 156545-07-2
3,5-difluorophenylboronic acid

: 1119204-93-1
3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]-N-prop-2-ynylbenzamide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water / 5 h / 100 °C

2: water; formic acid / 18 h / Heating

3: caesium carbonate / N,N-dimethyl-formamide / 20 h / 20 °C

4: sodium hydroxide; water / methanol / 18 h / Reflux

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 18 h / 20 °C

With formic acid; water; sodium carbonate; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 123577-99-1
3′,5′-difluoroacetophenone

: 1119204-93-1
3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]-N-prop-2-ynylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid / 18 h / 95 °C

1.2: 4 h / 30 - 95 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 20 h / 20 °C

3.1: sodium hydroxide; water / methanol / 18 h / Reflux

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 18 h / 20 °C

With water; benzotriazol-1-ol; caesium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In methanol; N,N-dimethyl-formamide;