(2S,3'S)-1-Acetyl-2-(2-benzyloxy-ethyl)-1'-((Z)-6-trimethylsilanyl-hex-4-enyl)-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-2',5'-dione

Base Information

Chemical Name:(2S,3'S)-1-Acetyl-2-(2-benzyloxy-ethyl)-1'-((Z)-6-trimethylsilanyl-hex-4-enyl)-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-2',5'-dione
CAS No.:132143-11-4
Molecular Formula:C₃₁H₄₀N₂O₄Si
Molecular Weight:532.755
Hs Code.:

Synonyms:(2S,3'S)-1-Acetyl-2-(2-benzyloxy-ethyl)-1'-((Z)-6-trimethylsilanyl-hex-4-enyl)-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-2',5'-dione

Suppliers and Price of (2S,3'S)-1-Acetyl-2-(2-benzyloxy-ethyl)-1'-((Z)-6-trimethylsilanyl-hex-4-enyl)-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-2',5'-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,3'S)-1-Acetyl-2-(2-benzyloxy-ethyl)-1'-((Z)-6-trimethylsilanyl-hex-4-enyl)-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-2',5'-dione

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,3'S)-1-Acetyl-2-(2-benzyloxy-ethyl)-1'-((Z)-6-trimethylsilanyl-hex-4-enyl)-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-2',5'-dione

There total 11 articles about (2S,3'S)-1-Acetyl-2-(2-benzyloxy-ethyl)-1'-((Z)-6-trimethylsilanyl-hex-4-enyl)-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-2',5'-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 132143-09-0
(2R,3'R)-1-Acetyl-2-(2-benzyloxy-ethyl)-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-2',5'-dione

: 97997-91-6
(Z)-6-(trimethylsilyl)hex-4-en-1-ol

: 132143-11-4
(2S,3'S)-1-Acetyl-2-(2-benzyloxy-ethyl)-1'-((Z)-6-trimethylsilanyl-hex-4-enyl)-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-2',5'-dione

Guidance literature:: With dimethyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; Ambient temperature;
DOI:10.1016/S0040-4020(01)90540-X

Reference yield: 82.0%

: 132143-12-5
(2S,3'S)-1-Acetyl-2-(2-benzyloxy-ethyl)-5'-hydroxy-1'-((Z)-6-trimethylsilanyl-hex-4-enyl)-1,2-dihydro-spiro[indole-3,3'-pyrrolidin]-2'-one

: 132143-11-4
(2S,3'S)-1-Acetyl-2-(2-benzyloxy-ethyl)-1'-((Z)-6-trimethylsilanyl-hex-4-enyl)-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-2',5'-dione

Guidance literature:: With pyridine; chromium(VI) oxide; In dichloromethane;
DOI:10.1016/S0040-4020(01)90540-X

Reference yield:

: 58594-50-6
3-(2'-nitrophenyl)pyrrolidine-2,5-dione

: 132143-11-4
(2S,3'S)-1-Acetyl-2-(2-benzyloxy-ethyl)-1'-((Z)-6-trimethylsilanyl-hex-4-enyl)-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-2',5'-dione

Guidance literature:: Multi-step reaction with 7 steps

1: Et₃N / DMAP / CH₂Cl₂ / 0 deg C to room temperature

2: 95 percent / H₂ / 10percent Pd/C / toluene; ethanol / 18 h / 760 Torr

3: toluene / Ambient temperature

4: 1.5 M n-BuLi / 2-methyl-propan-2-ol; tetrahydrofuran; hexane; toluene / 0.5 h / 5 °C

5: toluene

6: 20percent aq. HCl / ethanol / Ambient temperature

7: 98 percent / dimethyl azodicarboxylate, triphenylphosphine / tetrahydrofuran / Ambient temperature

With hydrogenchloride; n-butyllithium; hydrogen; dimethyl azodicarboxylate; triethylamine; triphenylphosphine; dmap; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane; dichloromethane; toluene; tert-butyl alcohol;
DOI:10.1016/S0040-4020(01)90540-X