(2R,3'R)-1-Acetyl-2-(2-benzyloxy-ethyl)-2'-ethoxy-1'-((Z)-6-trimethylsilanyl-hex-4-enyl)-1,2-dihydro-spiro[indole-3,3'-pyrrolidin]-5'-one

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Chemical Name:(2R,3'R)-1-Acetyl-2-(2-benzyloxy-ethyl)-2'-ethoxy-1'-((Z)-6-trimethylsilanyl-hex-4-enyl)-1,2-dihydro-spiro[indole-3,3'-pyrrolidin]-5'-one
CAS No.:132143-13-6
Molecular Formula:C₃₃H₄₆N₂O₄Si
Molecular Weight:562.825
Hs Code.:

Synonyms:(2R,3'R)-1-Acetyl-2-(2-benzyloxy-ethyl)-2'-ethoxy-1'-((Z)-6-trimethylsilanyl-hex-4-enyl)-1,2-dihydro-spiro[indole-3,3'-pyrrolidin]-5'-one

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Chemical Property of (2R,3'R)-1-Acetyl-2-(2-benzyloxy-ethyl)-2'-ethoxy-1'-((Z)-6-trimethylsilanyl-hex-4-enyl)-1,2-dihydro-spiro[indole-3,3'-pyrrolidin]-5'-one

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Technology Process of (2R,3'R)-1-Acetyl-2-(2-benzyloxy-ethyl)-2'-ethoxy-1'-((Z)-6-trimethylsilanyl-hex-4-enyl)-1,2-dihydro-spiro[indole-3,3'-pyrrolidin]-5'-one

There total 13 articles about (2R,3'R)-1-Acetyl-2-(2-benzyloxy-ethyl)-2'-ethoxy-1'-((Z)-6-trimethylsilanyl-hex-4-enyl)-1,2-dihydro-spiro[indole-3,3'-pyrrolidin]-5'-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 58594-50-6
3-(2'-nitrophenyl)pyrrolidine-2,5-dione

: 132143-13-6
(2R,3'R)-1-Acetyl-2-(2-benzyloxy-ethyl)-2'-ethoxy-1'-((Z)-6-trimethylsilanyl-hex-4-enyl)-1,2-dihydro-spiro[indole-3,3'-pyrrolidin]-5'-one

Guidance literature:: Multi-step reaction with 9 steps

1: Et₃N / DMAP / CH₂Cl₂ / 0 deg C to room temperature

2: 95 percent / H₂ / 10percent Pd/C / toluene; ethanol / 18 h / 760 Torr

3: toluene / Ambient temperature

4: 1.5 M n-BuLi / 2-methyl-propan-2-ol; tetrahydrofuran; hexane; toluene / 0.5 h / 5 °C

5: toluene

6: 20percent aq. HCl / ethanol / Ambient temperature

7: 98 percent / dimethyl azodicarboxylate, triphenylphosphine / tetrahydrofuran / Ambient temperature

8: 54 percent / NaBH₄, 2 N H₂SO₄ / ethanol / 0 °C

9: 1.) Et₃N, MeSO₂Cl / 1.) THF, -30 deg C to room temperature, 15 min, 2.) 90 min

With hydrogenchloride; sodium tetrahydroborate; n-butyllithium; sulfuric acid; hydrogen; methanesulfonyl chloride; dimethyl azodicarboxylate; triethylamine; triphenylphosphine; dmap; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane; dichloromethane; toluene; tert-butyl alcohol;
DOI:10.1016/S0040-4020(01)90540-X

Reference yield:

: 132143-08-9
1-(tert-Butyl-dimethyl-silanyl)-3-(2-nitro-phenyl)-pyrrolidine-2,5-dione

: 132143-13-6
(2R,3'R)-1-Acetyl-2-(2-benzyloxy-ethyl)-2'-ethoxy-1'-((Z)-6-trimethylsilanyl-hex-4-enyl)-1,2-dihydro-spiro[indole-3,3'-pyrrolidin]-5'-one

Guidance literature:: Multi-step reaction with 8 steps

1: 95 percent / H₂ / 10percent Pd/C / toluene; ethanol / 18 h / 760 Torr

2: toluene / Ambient temperature

3: 1.5 M n-BuLi / 2-methyl-propan-2-ol; tetrahydrofuran; hexane; toluene / 0.5 h / 5 °C

4: toluene

5: 20percent aq. HCl / ethanol / Ambient temperature

6: 98 percent / dimethyl azodicarboxylate, triphenylphosphine / tetrahydrofuran / Ambient temperature

7: 54 percent / NaBH₄, 2 N H₂SO₄ / ethanol / 0 °C

8: 1.) Et₃N, MeSO₂Cl / 1.) THF, -30 deg C to room temperature, 15 min, 2.) 90 min

With hydrogenchloride; sodium tetrahydroborate; n-butyllithium; sulfuric acid; hydrogen; methanesulfonyl chloride; dimethyl azodicarboxylate; triethylamine; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane; toluene; tert-butyl alcohol;
DOI:10.1016/S0040-4020(01)90540-X

Reference yield:

: 772-01-0
2-phenyl-1,3-dioxane

: 132143-13-6
(2R,3'R)-1-Acetyl-2-(2-benzyloxy-ethyl)-2'-ethoxy-1'-((Z)-6-trimethylsilanyl-hex-4-enyl)-1,2-dihydro-spiro[indole-3,3'-pyrrolidin]-5'-one

Guidance literature:: Multi-step reaction with 9 steps

1: 93 percent / 1.5 M DIBAL-H / toluene / Ambient temperature

2: 82 percent / pyridine/CrO₃ complex / CH₂Cl₂

3: toluene / Ambient temperature

4: 1.5 M n-BuLi / 2-methyl-propan-2-ol; tetrahydrofuran; hexane; toluene / 0.5 h / 5 °C

5: toluene

6: 20percent aq. HCl / ethanol / Ambient temperature

7: 98 percent / dimethyl azodicarboxylate, triphenylphosphine / tetrahydrofuran / Ambient temperature

8: 54 percent / NaBH₄, 2 N H₂SO₄ / ethanol / 0 °C

9: 1.) Et₃N, MeSO₂Cl / 1.) THF, -30 deg C to room temperature, 15 min, 2.) 90 min

With pyridine; chromium(VI) oxide; hydrogenchloride; sodium tetrahydroborate; n-butyllithium; sulfuric acid; diisobutylaluminium hydride; methanesulfonyl chloride; dimethyl azodicarboxylate; triethylamine; triphenylphosphine; In tetrahydrofuran; ethanol; hexane; dichloromethane; toluene; tert-butyl alcohol;
DOI:10.1016/S0040-4020(01)90540-X