(2R,3R)-2,3-bis[(4-methylbenzoyl)oxy]butanedioic acid; tert-butyl (3R,4R)-3-amino-4-(hydroxymethyl)-3-isothiazol-5-yl-pyrrolidine-1-carboxylate

Base Information

Chemical Name:(2R,3R)-2,3-bis[(4-methylbenzoyl)oxy]butanedioic acid; tert-butyl (3R,4R)-3-amino-4-(hydroxymethyl)-3-isothiazol-5-yl-pyrrolidine-1-carboxylate
CAS No.:1463486-07-8
Molecular Formula:C₁₃H₂₁N₃O₃S*C₂₀H₁₈O₈
Molecular Weight:685.752
Hs Code.:

Synonyms:(2R,3R)-2,3-bis[(4-methylbenzoyl)oxy]butanedioic acid; tert-butyl (3R,4R)-3-amino-4-(hydroxymethyl)-3-isothiazol-5-yl-pyrrolidine-1-carboxylate

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Chemical Property of (2R,3R)-2,3-bis[(4-methylbenzoyl)oxy]butanedioic acid; tert-butyl (3R,4R)-3-amino-4-(hydroxymethyl)-3-isothiazol-5-yl-pyrrolidine-1-carboxylate

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Technology Process of (2R,3R)-2,3-bis[(4-methylbenzoyl)oxy]butanedioic acid; tert-butyl (3R,4R)-3-amino-4-(hydroxymethyl)-3-isothiazol-5-yl-pyrrolidine-1-carboxylate

There total 7 articles about (2R,3R)-2,3-bis[(4-methylbenzoyl)oxy]butanedioic acid; tert-butyl (3R,4R)-3-amino-4-(hydroxymethyl)-3-isothiazol-5-yl-pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.7%

: 32634-66-5
Di-p-toluoyl-L-tartaric acid

: 1463484-93-6
tert-butyl 3-amino-4-(hydroxymethyl)-3-isothiazol-5-yl-pyrrolidine-1-carboxylate

: 1463486-07-8
(2R,3R)-2,3-bis[(4-methylbenzoyl)oxy]butanedioic acid; tert-butyl (3R,4R)-3-amino-4-(hydroxymethyl)-3-isothiazol-5-yl-pyrrolidine-1-carboxylate

Guidance literature:: In isopropyl alcohol; at 70 ℃; for 0.5h;

Reference yield:

: 1463484-92-5
tert-butyl 6a-isothiazol-5-yl-1-[(4-methoxyphenyl)methyl]-3,3a,4,6-tetrahydropyrrolo[3,4-c]isoxazole-5-carboxylate

: 1463486-07-8
(2R,3R)-2,3-bis[(4-methylbenzoyl)oxy]butanedioic acid; tert-butyl (3R,4R)-3-amino-4-(hydroxymethyl)-3-isothiazol-5-yl-pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetyl chloride; isopropyl alcohol / 1 h / 45 °C

1.2: 1 h / 70 °C

1.3: 1 h / 10 - 25 °C

2.1: zinc; acetic acid / 8 h / 40 °C

3.1: isopropyl alcohol / 0.5 h / 70 °C

With acetic acid; acetyl chloride; isopropyl alcohol; zinc; In isopropyl alcohol;

Reference yield:

: 1463484-63-0
tert-butyl 6a-isothiazol-5-yl-3,3a,4,6-tetrahydro-1H-pyrrolo[3,4-c]isoxazole-5-carboxylate

: 1463486-07-8
(2R,3R)-2,3-bis[(4-methylbenzoyl)oxy]butanedioic acid; tert-butyl (3R,4R)-3-amino-4-(hydroxymethyl)-3-isothiazol-5-yl-pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: zinc; acetic acid / 8 h / 40 °C

2: isopropyl alcohol / 0.5 h / 70 °C

With acetic acid; zinc; In isopropyl alcohol;