tert-butyl(3R,4R)-3-amino-4-(hydroxymethyl)-3-(isothiazol-5-yl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:tert-butyl(3R,4R)-3-amino-4-(hydroxymethyl)-3-(isothiazol-5-yl)pyrrolidine-1-carboxylate
CAS No.:1463486-06-7
Molecular Formula:C₁₃H₂₁N₃O₃S
Molecular Weight:299.394
Hs Code.:
Mol file:1463486-06-7.mol

Synonyms:tert-butyl (3R,4R)-3-amino-4-(hydroxymethyl)-3-isothiazol-5-yl-pyrrolidine-1-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl(3R,4R)-3-amino-4-(hydroxymethyl)-3-(isothiazol-5-yl)pyrrolidine-1-carboxylate

Chemical Property:

Boiling Point:383.0±42.0 °C(Predicted)
PKA:14.93±0.10(Predicted)
Density:1?+-.0.06 g/cm3(Predicted)

Purity/Quality:

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Technology Process of tert-butyl(3R,4R)-3-amino-4-(hydroxymethyl)-3-(isothiazol-5-yl)pyrrolidine-1-carboxylate

There total 8 articles about tert-butyl(3R,4R)-3-amino-4-(hydroxymethyl)-3-(isothiazol-5-yl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1463486-07-8
(2R,3R)-2,3-bis[(4-methylbenzoyl)oxy]butanedioic acid; tert-butyl (3R,4R)-3-amino-4-(hydroxymethyl)-3-isothiazol-5-yl-pyrrolidine-1-carboxylate

: 1463486-06-7
tert-butyl (3R,4R)-3-amino-4-(hydroxymethyl)-3-isothiazol-5-yl-pyrrolidine-1-carboxylate

Guidance literature:: With hydrogenchloride; In water; ethyl acetate; at 20 ℃; for 0.25h; pH=2;

Reference yield:

: 1463484-92-5
tert-butyl 6a-isothiazol-5-yl-1-[(4-methoxyphenyl)methyl]-3,3a,4,6-tetrahydropyrrolo[3,4-c]isoxazole-5-carboxylate

: 1463486-06-7
tert-butyl (3R,4R)-3-amino-4-(hydroxymethyl)-3-isothiazol-5-yl-pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetyl chloride; isopropyl alcohol / 1 h / 45 °C

1.2: 1 h / 70 °C

1.3: 1 h / 10 - 25 °C

2.1: zinc; acetic acid / 8 h / 40 °C

3.1: isopropyl alcohol / 0.5 h / 70 °C

4.1: hydrogenchloride / water; ethyl acetate / 0.25 h / 20 °C / pH 2

With hydrogenchloride; acetic acid; acetyl chloride; isopropyl alcohol; zinc; In water; ethyl acetate; isopropyl alcohol;

Reference yield:

: 1463484-63-0
tert-butyl 6a-isothiazol-5-yl-3,3a,4,6-tetrahydro-1H-pyrrolo[3,4-c]isoxazole-5-carboxylate

: 1463486-06-7
tert-butyl (3R,4R)-3-amino-4-(hydroxymethyl)-3-isothiazol-5-yl-pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: zinc; acetic acid / 8 h / 40 °C

2: isopropyl alcohol / 0.5 h / 70 °C

3: hydrogenchloride / water; ethyl acetate / 0.25 h / 20 °C / pH 2

With hydrogenchloride; acetic acid; zinc; In water; ethyl acetate; isopropyl alcohol;