3,4-Pyridinediamine,N3-methyl-(9CI)

Base Information

• Chemical Name: 3,4-Pyridinediamine,N3-methyl-(9CI)
• CAS No.: 1796-73-2
• Molecular Formula: C6H9N3
• Molecular Weight: 123.16
• Hs Code.: 2933399090
• Mol file: 1796-73-2.mol

Synonyms:3,4-Pyridinediamine,N3-methyl-(9CI)

Chemical Property of 3,4-Pyridinediamine,N3-methyl-(9CI)

Chemical Property:

• Boiling Point: 325.0±27.0 °C(Predicted)
• PKA: 9.49±0.18(Predicted)
• PSA: 51.67000
• Density: 1.179±0.06 g/cm3(Predicted)
• LogP: 0.70860

Purity/Quality:

NLT 98% ^*data from raw suppliers

N3-methylpyridine-3,4-diamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,4-Pyridinediamine,N3-methyl-(9CI)

There total 6 articles about 3,4-Pyridinediamine,N3-methyl-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-methyl-4-nitro-3-pyridineamine 1-oxide (1796-82-3) → 4-amino-3-N-methylaminopyridine (1796-73-2)

Guidance literature:

With hydrogen; nickel; In methanol;

Reference yield:

3-(methylamino)-4-nitropyridine (221636-01-7) → 4-amino-3-N-methylaminopyridine (1796-73-2)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; 1,2-dimethoxyethane; at 20 ℃; under 2068.65 Torr;

DOI:10.1016/j.bmcl.2008.09.026

Reference yield:

3-chloro-4-nitropyridine N-oxide (76439-45-7) → 4-amino-3-N-methylaminopyridine (1796-73-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / CHCl₃ / 0.25 h / 0 °C

2: H₂ / 5percent Pd/C / ethanol

With hydrogen; palladium on activated charcoal; In ethanol; chloroform;

DOI:10.1002/jhet.5570270316

upstream raw materials:

N-methyl-4-nitro-3-pyridineamine 1-oxide

3-bromopyridine N-oxide

3-Bromo-4-nitropyridine N-oxide

3-chloro-4-nitropyridine N-oxide

Downstream raw materials:

4-methyl-2,3(1H)-dioxo-pyrazino-[5,6-c]pyridine

1,4-dihydro-pyrido[3,4-b]pyrazine-2,3-dione

2-(2,4-dimethoxyphenyl)-3-methylimidazo<4,5-c>pyridine hydrochloride

3-methylimidazo<4,5-c>pyridine

Refernces

• 1、 Zhang, Lei,Rogers, Bruce N.,Duplantier, Allen J.,McHardy, Stanley F.,Efremov, Ivan,Berke, Helen,Qian, Weimin,Zhang, Andy Q.,Maklad, Noha,Candler, John,Doran, Angela C.,Lazzaro Jr., John T.,Ganong, Alan H.. "3-(Imidazolyl methyl)-3-aza-bicyclo[3.1.0]hexan-6-yl)methyl ethers: A novel series of mGluR2 positive allosteric modulators". scheme or table. p. 5493 - 5496. Retrieved 2009/06/18.
• 2、 Katner,Brown. "A novel preparation of thiazolo[5,4-c]pyridines and the synthesis of some imidazo[5,4-c]pyridines and oxazolo[4,5-c] pyridines". . p. 563 - 566. Retrieved 2007/10/02.