diisopropyl 6-N-benzoyl-β-D-arabinoadenosin-5'-O-ylmethanephosphonate

Base Information

• Chemical Name: diisopropyl 6-N-benzoyl-β-D-arabinoadenosin-5'-O-ylmethanephosphonate
• CAS No.: 1357015-86-1
• Molecular Formula: C₂₄H₃₂N₅O₈P
• Molecular Weight: 549.521
• Mol file: 1357015-86-1.mol

Synonyms:diisopropyl 6-N-benzoyl-β-D-arabinoadenosin-5'-O-ylmethanephosphonate

Chemical Property of diisopropyl 6-N-benzoyl-β-D-arabinoadenosin-5'-O-ylmethanephosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diisopropyl 6-N-benzoyl-β-D-arabinoadenosin-5'-O-ylmethanephosphonate

There total 3 articles about diisopropyl 6-N-benzoyl-β-D-arabinoadenosin-5'-O-ylmethanephosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C34H48N5O10P → diisopropyl 6-N-benzoyl-β-D-arabinoadenosin-5'-O-ylmethanephosphonate (1357015-86-1)

Guidance literature:

With acetic acid; at 20 ℃; for 16h;

DOI:10.1016/j.bmcl.2011.11.040

Reference yield:

6-N-benzoyl-2',3'-O-bis-tetrahydropyranyl-β-D-arabinoadenosine (1357015-83-8) → diisopropyl 6-N-benzoyl-β-D-arabinoadenosin-5'-O-ylmethanephosphonate (1357015-86-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

2: acetic acid / 16 h / 20 °C

With sodium hydride; acetic acid; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.11.040

Reference yield:

bis(2-propyl)-p-toluenesulfonyloxymethylphosphonate (35717-98-7) → diisopropyl 6-N-benzoyl-β-D-arabinoadenosin-5'-O-ylmethanephosphonate (1357015-86-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

2: acetic acid / 16 h / 20 °C

With sodium hydride; acetic acid; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.11.040

upstream raw materials:

6-N-benzoyl-2',3'-O-bis-tetrahydropyranyl-β-D-arabinoadenosine

bis(2-propyl)-p-toluenesulfonyloxymethylphosphonate

Downstream raw materials:

diisopropyl 3'-O-benzoyl-6-N-benzoyl-2'-O-dimethoxytrityl-β-D-arabinoadenosin-5'-O-ylmethanephosphonate

C₅₂H₅₄N₅O₁₁P

4-methoxy-1-oxido-2-pyridylmethyl 6-N-benzoyl-3'-O-benzoyl-2'-O-dimethoxytrityl-β-D-arabinoadenosin-5'-O-ylmethanephosphonate