4-methoxy-1-oxido-2-pyridylmethyl 6-N-benzoyl-3'-O-benzoyl-2'-O-dimethoxytrityl-β-D-arabinoadenosin-5'-O-ylmethanephosphonate

Base Information

• Chemical Name: 4-methoxy-1-oxido-2-pyridylmethyl 6-N-benzoyl-3'-O-benzoyl-2'-O-dimethoxytrityl-β-D-arabinoadenosin-5'-O-ylmethanephosphonate
• CAS No.: 1357015-97-4
• Molecular Formula: C₅₃H₄₉N₆O₁₃P
• Molecular Weight: 1008.98
• Mol file: 1357015-97-4.mol

Synonyms:4-methoxy-1-oxido-2-pyridylmethyl 6-N-benzoyl-3'-O-benzoyl-2'-O-dimethoxytrityl-β-D-arabinoadenosin-5'-O-ylmethanephosphonate

Chemical Property of 4-methoxy-1-oxido-2-pyridylmethyl 6-N-benzoyl-3'-O-benzoyl-2'-O-dimethoxytrityl-β-D-arabinoadenosin-5'-O-ylmethanephosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-methoxy-1-oxido-2-pyridylmethyl 6-N-benzoyl-3'-O-benzoyl-2'-O-dimethoxytrityl-β-D-arabinoadenosin-5'-O-ylmethanephosphonate

There total 8 articles about 4-methoxy-1-oxido-2-pyridylmethyl 6-N-benzoyl-3'-O-benzoyl-2'-O-dimethoxytrityl-β-D-arabinoadenosin-5'-O-ylmethanephosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C60H56N7O15P → 4-methoxy-1-oxido-2-pyridylmethyl 6-N-benzoyl-3'-O-benzoyl-2'-O-dimethoxytrityl-β-D-arabinoadenosin-5'-O-ylmethanephosphonate (1357015-97-4)

Guidance literature:

With thiophenol; triethylamine; In 1,4-dioxane; N,N-dimethyl-formamide; at 20 ℃; for 1h;

DOI:10.1016/j.bmcl.2011.11.040

Reference yield:

C46H42N5O11P → 4-methoxy-1-oxido-2-pyridylmethyl 6-N-benzoyl-3'-O-benzoyl-2'-O-dimethoxytrityl-β-D-arabinoadenosin-5'-O-ylmethanephosphonate (1357015-97-4)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine; 4-methoxypyridine N-oxide; 2-chloro-5,5-dimethyl[1,3,2]dioxaphosphinane 2-oxide / 16 h / 20 °C

2: thiophenol; triethylamine / 1,4-dioxane; N,N-dimethyl-formamide / 1 h / 20 °C

With pyridine; 4-methoxypyridine N-oxide; 2-chloro-5,5-dimethyl[1,3,2]dioxaphosphinane 2-oxide; thiophenol; triethylamine; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.11.040

Reference yield:

diisopropyl 3'-O-benzoyl-6-N-benzoyl-2'-O-dimethoxytrityl-β-D-arabinoadenosin-5'-O-ylmethanephosphonate (1357015-90-7) → 4-methoxy-1-oxido-2-pyridylmethyl 6-N-benzoyl-3'-O-benzoyl-2'-O-dimethoxytrityl-β-D-arabinoadenosin-5'-O-ylmethanephosphonate (1357015-97-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 2,6-dimethylpyridine; trimethylsilyl bromide / acetonitrile / 16 h / 20 °C

2: pyridine; 4-methoxypyridine N-oxide; 2-chloro-5,5-dimethyl[1,3,2]dioxaphosphinane 2-oxide / 16 h / 20 °C

3: thiophenol; triethylamine / 1,4-dioxane; N,N-dimethyl-formamide / 1 h / 20 °C

With pyridine; 2,6-dimethylpyridine; 4-methoxypyridine N-oxide; 2-chloro-5,5-dimethyl[1,3,2]dioxaphosphinane 2-oxide; trimethylsilyl bromide; thiophenol; triethylamine; In 1,4-dioxane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/j.bmcl.2011.11.040

upstream raw materials:

benzoyl cyanide

6-N-benzoyl-2',3'-O-bis-tetrahydropyranyl-β-D-arabinoadenosine

diisopropyl 6-N-benzoyl-β-D-arabinoadenosin-5'-O-ylmethanephosphonate

diisopropyl 3'-O-benzoyl-6-N-benzoyl-2'-O-dimethoxytrityl-β-D-arabinoadenosin-5'-O-ylmethanephosphonate