(R)-N-[1-(3-acetylamino-2-methoxyphenyl)-2-(tert-butyldiphenylsilanyloxy)ethyl]-2-hydroxy-N-(4-methoxybenzyl)acetamide

Base Information

• Chemical Name: (R)-N-[1-(3-acetylamino-2-methoxyphenyl)-2-(tert-butyldiphenylsilanyloxy)ethyl]-2-hydroxy-N-(4-methoxybenzyl)acetamide
• CAS No.: 340963-51-1
• Molecular Formula: C₃₇H₄₄N₂O₆Si
• Molecular Weight: 640.852

Synonyms:(R)-N-[1-(3-acetylamino-2-methoxyphenyl)-2-(tert-butyldiphenylsilanyloxy)ethyl]-2-hydroxy-N-(4-methoxybenzyl)acetamide

Chemical Property of (R)-N-[1-(3-acetylamino-2-methoxyphenyl)-2-(tert-butyldiphenylsilanyloxy)ethyl]-2-hydroxy-N-(4-methoxybenzyl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-N-[1-(3-acetylamino-2-methoxyphenyl)-2-(tert-butyldiphenylsilanyloxy)ethyl]-2-hydroxy-N-(4-methoxybenzyl)acetamide

There total 12 articles about (R)-N-[1-(3-acetylamino-2-methoxyphenyl)-2-(tert-butyldiphenylsilanyloxy)ethyl]-2-hydroxy-N-(4-methoxybenzyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(R)-acetic acid [[1-(3-acetylamino-2-methoxyphenyl)-2-(tert-butyldiphenylsilanyloxy)ethyl]-(4-methoxybenzyl)carbamoyl]methyl ester (340963-48-6) → (R)-N-[1-(3-acetylamino-2-methoxyphenyl)-2-(tert-butyldiphenylsilanyloxy)ethyl]-2-hydroxy-N-(4-methoxybenzyl)acetamide (340963-51-1)

Guidance literature:

With potassium carbonate; In methanol; water; for 1.5h;

DOI:10.1021/jo015512q

Reference yield:

1-(2-methoxyphenyl)ethane-1,2-diol (82807-38-3) → (R)-N-[1-(3-acetylamino-2-methoxyphenyl)-2-(tert-butyldiphenylsilanyloxy)ethyl]-2-hydroxy-N-(4-methoxybenzyl)acetamide (340963-51-1)

Guidance literature:

Multi-step reaction with 11 steps

1: 94 percent / pyridine / 8 h / 20 °C

2: 83 percent / KNO₃; TFAA / CHCl₃ / 48 h / 0 °C

3: 93 percent / K₂CO₃ / methanol; H₂O / 0.5 h

4: 73 percent / imidazole / dimethylformamide / 4 h / 20 °C

5: 89 percent / PPh₃; DEAD / tetrahydrofuran / 1.5 h

6: 100 percent / NH₂NH₂*H₂O / ethanol / 3 h / Heating

7: 84 percent / NaBH₃CN; AcOH / methanol / 0 - 20 °C

8: 74 percent / NMM; isobutyl chloroformate / CH₂Cl₂ / 12 h / 20 °C

9: H₂ / 10percent Pd/C / propan-1-ol / 4 h / 760.05 Torr

10: 3.732 g / Et₃N / CH₂Cl₂ / 12 h / 20 °C

11: 89 percent / K₂CO₃ / methanol; H₂O / 1.5 h

With 4-methyl-morpholine; 1H-imidazole; hydrogen; sodium cyanoborohydride; potassium carbonate; hydrazine hydrate; acetic acid; potassium nitrate; triethylamine; triphenylphosphine; trifluoroacetic anhydride; diethylazodicarboxylate; isobutyl chloroformate; 10percent Pd/C; In tetrahydrofuran; pyridine; methanol; propan-1-ol; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; 5: Mitsunobu reaction;

DOI:10.1021/jo015512q

Reference yield:

tert-butylchlorodiphenylsilane (58479-61-1) → (R)-N-[1-(3-acetylamino-2-methoxyphenyl)-2-(tert-butyldiphenylsilanyloxy)ethyl]-2-hydroxy-N-(4-methoxybenzyl)acetamide (340963-51-1)

Guidance literature:

Multi-step reaction with 8 steps

1: 73 percent / imidazole / dimethylformamide / 4 h / 20 °C

2: 89 percent / PPh₃; DEAD / tetrahydrofuran / 1.5 h

3: 100 percent / NH₂NH₂*H₂O / ethanol / 3 h / Heating

4: 84 percent / NaBH₃CN; AcOH / methanol / 0 - 20 °C

5: 74 percent / NMM; isobutyl chloroformate / CH₂Cl₂ / 12 h / 20 °C

6: H₂ / 10percent Pd/C / propan-1-ol / 4 h / 760.05 Torr

7: 3.732 g / Et₃N / CH₂Cl₂ / 12 h / 20 °C

8: 89 percent / K₂CO₃ / methanol; H₂O / 1.5 h

With 4-methyl-morpholine; 1H-imidazole; hydrogen; sodium cyanoborohydride; potassium carbonate; hydrazine hydrate; acetic acid; triethylamine; triphenylphosphine; diethylazodicarboxylate; isobutyl chloroformate; 10percent Pd/C; In tetrahydrofuran; methanol; propan-1-ol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; 2: Mitsunobu reaction;

DOI:10.1021/jo015512q

upstream raw materials:

(R)-acetic acid [[1-(3-acetylamino-2-methoxyphenyl)-2-(tert-butyldiphenylsilanyloxy)ethyl]-(4-methoxybenzyl)carbamoyl]methyl ester

1-(2-methoxyphenyl)ethane-1,2-diol

tert-butylchlorodiphenylsilane

(S)-1-(2-methoxy-3-nitrophenyl)ethane-1,2-diol

Downstream raw materials:

N-[1-(3-acetylamino-2-methoxy-phenyl)-2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-N-(4-methoxy-benzyl)-2-oxo-acetamide

(R)-N-[1-(tert-butyldiphenylsilanyloxy)-4-hydroxy-8-methoxy-2-(4-methoxybenzyl)-3-oxo-1,2,3,4-tetrahydroisoquinolin-7-yl]acetamide

thiocarbonic acid O-[7-acetylamino-1-(tert-butyl-diphenyl-silanyloxymethyl)-8-methoxy-2-(4-methoxy-benzyl)-3-oxo-1,2,3,4-tetrahydro-isoquinolin-4-yl] ester O-phenyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 340963-51-1 (R)-N-[1-(3-acetylamino-2-methoxyphenyl)-2-(tert-butyldiphenylsilanyloxy)ethyl]-2-hydroxy-N-(4-methoxybenzyl)acetamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send