(E)-methyl 2-(tert-butyloxycarbonylamino)-4-(1-benzyloxycarbonylpiperidin-4-yl)but-2-enoate

Base Information

Chemical Name:(E)-methyl 2-(tert-butyloxycarbonylamino)-4-(1-benzyloxycarbonylpiperidin-4-yl)but-2-enoate
CAS No.:1322746-27-9
Molecular Formula:C₂₃H₃₂N₂O₆
Molecular Weight:432.517
Hs Code.:

Synonyms:(E)-methyl 2-(tert-butyloxycarbonylamino)-4-(1-benzyloxycarbonylpiperidin-4-yl)but-2-enoate

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Chemical Property of (E)-methyl 2-(tert-butyloxycarbonylamino)-4-(1-benzyloxycarbonylpiperidin-4-yl)but-2-enoate

Chemical Property:

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Technology Process of (E)-methyl 2-(tert-butyloxycarbonylamino)-4-(1-benzyloxycarbonylpiperidin-4-yl)but-2-enoate

There total 1 articles about (E)-methyl 2-(tert-butyloxycarbonylamino)-4-(1-benzyloxycarbonylpiperidin-4-yl)but-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 130312-10-6
benzyl 4-(2-oxoethyl)piperidine-1-carboxylate

: 121056-95-9,89524-98-1
trimethyl 2-(tert-butoxycarbonylamino)phosphonoacetate

: 1322746-27-9
(E)-methyl 2-(tert-butyloxycarbonylamino)-4-(1-benzyloxycarbonylpiperidin-4-yl)but-2-enoate

Guidance literature:: trimethyl 2-(tert-butoxycarbonylamino)phosphonoacetate; With N,N,N',N'-tetramethylguanidine; In tetrahydrofuran; at -78 ℃; for 0.333333h;

benzyl 4-(2-oxoethyl)piperidine-1-carboxylate; In tetrahydrofuran; at -78 - 0 ℃;

Reference yield: 97.0%

: 1322746-27-9
(E)-methyl 2-(tert-butyloxycarbonylamino)-4-(1-benzyloxycarbonylpiperidin-4-yl)but-2-enoate

: 1322746-28-0
(S)-2-tert-butyloxycarbonylamino-4-(1-benzyloxycarbonylpiperidin-4-yl)butanoic acid methyl ester

Guidance literature:: With hydrogen; (+)-1,2-bis-((2S,5S)-2,5-diethylphospholano)benzene(cyclooctadiene)rhodium(I) trifluoromethanesulfonate; In methanol; at 20 ℃; for 18.5h; under 3000.3 Torr; Inert atmosphere;

Reference yield:

: 1322746-27-9
(E)-methyl 2-(tert-butyloxycarbonylamino)-4-(1-benzyloxycarbonylpiperidin-4-yl)but-2-enoate

: 1322746-29-1
(S)-2-tert-butyloxycarbonylamino-4-(1-benzyloxycarbonylpiperidin-4-yl)butanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / (+)-1,2-bis-((2S,5S)-2,5-diethylphospholano)benzene(cyclooctadiene)rhodium(I) trifluoromethanesulfonate / methanol / 18.5 h / 20 °C / 3000.3 Torr / Inert atmosphere

2: lithium hydroxide / 1,4-dioxane; water / 2 h / 20 °C

With hydrogen; lithium hydroxide; (+)-1,2-bis-((2S,5S)-2,5-diethylphospholano)benzene(cyclooctadiene)rhodium(I) trifluoromethanesulfonate; In 1,4-dioxane; methanol; water;