N-(2,2-Difluoro-6-nitro-benzo[1,3]dioxol-5-yl)acetamide

Base Information

• Chemical Name: N-(2,2-Difluoro-6-nitro-benzo[1,3]dioxol-5-yl)acetamide
• CAS No.: 1736-66-9
• Molecular Formula: C₉H₆F₂N₂O₅
• Molecular Weight: 260.154
• Hs Code.: 2932999099
• Mol file: 1736-66-9.mol

Synonyms:Acetanilide,4',5'-[(difluoromethylene)dioxy]-2'-nitro- (7CI,8CI)

Chemical Property of N-(2,2-Difluoro-6-nitro-benzo[1,3]dioxol-5-yl)acetamide

Chemical Property:

• Melting Point: 89-900C
• Refractive Index: 1.566
• PSA: 93.38000
• LogP: 2.47090
• Storage Temp.: Refrigerator
• Solubility.: Chloroform, Methanol

Purity/Quality:

99% ^*data from raw suppliers

N-(2,2-Difluoro-6-nitro-benzo[1,3]dioxol-5-yl)acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-(2,2-Difluoro-6-nitro-benzo[1,3]dioxol-5-yl)acetamide (cas# 1736-66-9) is a compound useful in organic synthesis.

Technology Process of N-(2,2-Difluoro-6-nitro-benzo[1,3]dioxol-5-yl)acetamide

There total 3 articles about N-(2,2-Difluoro-6-nitro-benzo[1,3]dioxol-5-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

N-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)acetamide (948-94-7) → N-(2,2-difluoro-6-nitrobenzo[d][1,3]dioxol-5-yl)acetamide (1736-66-9)

Guidance literature:

With nitric acid; acetic acid; at 25 - 60 ℃;

Reference yield:

2,2-difluoro-benzo[1,3]dioxol-5-ylamine (1544-85-0) → N-(2,2-difluoro-6-nitrobenzo[d][1,3]dioxol-5-yl)acetamide (1736-66-9)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / 2 h / 100 °C

2: acetic acid; nitric acid / 25 - 60 °C

With nitric acid; acetic acid; In toluene;

Reference yield:

→ N-(2,2-difluoro-6-nitrobenzo[d][1,3]dioxol-5-yl)acetamide (1736-66-9)

Guidance literature:

4-Acetamino-1,2-difluormethylendioxy-benzol, HNO3 (D: 1.41), H2SO4 (D:1.83) <2h, 0grad bis 2grad>;

upstream raw materials:

2,2-difluoro-benzo[1,3]dioxol-5-ylamine

N-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)acetamide

Downstream raw materials:

2,2-difluoro-6-nitrobenzo[d][1,3]dioxol-5-amine

2,2-difluorobenzo[d][1,3]dioxole-5,6-diamine