(R)-2-(6-((R)-(4-fluorophenyl)(4-methylpiperidin-1-yl)methyl)-4'-(trifluoromethyl)biphenyl-3-yl)propanoic acid

Base Information

Chemical Name:(R)-2-(6-((R)-(4-fluorophenyl)(4-methylpiperidin-1-yl)methyl)-4'-(trifluoromethyl)biphenyl-3-yl)propanoic acid
CAS No.:1257396-73-8
Molecular Formula:C₂₉H₂₉F₄NO₂
Molecular Weight:499.548
Hs Code.:

Synonyms:(R)-2-(6-((R)-(4-fluorophenyl)(4-methylpiperidin-1-yl)methyl)-4'-(trifluoromethyl)biphenyl-3-yl)propanoic acid

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Chemical Property of (R)-2-(6-((R)-(4-fluorophenyl)(4-methylpiperidin-1-yl)methyl)-4'-(trifluoromethyl)biphenyl-3-yl)propanoic acid

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Technology Process of (R)-2-(6-((R)-(4-fluorophenyl)(4-methylpiperidin-1-yl)methyl)-4'-(trifluoromethyl)biphenyl-3-yl)propanoic acid

There total 10 articles about (R)-2-(6-((R)-(4-fluorophenyl)(4-methylpiperidin-1-yl)methyl)-4'-(trifluoromethyl)biphenyl-3-yl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 42058-59-3
3-hydroxy-benzeneacetic acid, methyl ester

: 1257396-73-8
(R)-2-(6-((R)-(4-fluorophenyl)(4-methylpiperidin-1-yl)methyl)-4'-(trifluoromethyl)biphenyl-3-yl)propanoic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium carbonate / acetonitrile / 6 h / 20 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: 17 h / -78 - 20 °C / Inert atmosphere

3.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h

4.1: 4-methyl-1,2,3-trifluorobenzene / 1 h / 120 °C / Microwave irradiation; Inert atmosphere

5.1: pyridine / dichloromethane / 2 h / 20 °C / Inert atmosphere

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; water; toluene / 4 h / 80 °C / Inert atmosphere

7.1: water; sodium hydroxide / tetrahydrofuran; methanol / 0.17 h / 100 °C / Microwave irradiation; Inert atmosphere

8.1: carbon dioxide / methanol; isopropyl alcohol / 75007.5 Torr / Resolution of racemate; Inert atmosphere

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; carbon dioxide; palladium 10% on activated carbon; water; hydrogen; sodium carbonate; potassium carbonate; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; isopropyl alcohol; toluene; acetonitrile; 4-methyl-1,2,3-trifluorobenzene; 4.1: Mannich reaction / 6.1: Suzuki coupling;
DOI:10.1021/ml200175q

Reference yield:

: 1257395-14-4
2-(6-((4-fluorophenyl)(4-methylpiperidin-1-yl)methyl)-4'-(trifluoromethyl)biphenyl-3-yl)propanoic acid

: 1257396-73-8
(R)-2-(6-((R)-(4-fluorophenyl)(4-methylpiperidin-1-yl)methyl)-4'-(trifluoromethyl)biphenyl-3-yl)propanoic acid

Guidance literature:: With carbon dioxide; In methanol; isopropyl alcohol; under 75007.5 Torr; Resolution of racemate; Inert atmosphere;
DOI:10.1021/ml200175q

Reference yield:

: 62969-42-0
3-benzyloxy-phenylacetic acid methyl ester

: 1257396-73-8
(R)-2-(6-((R)-(4-fluorophenyl)(4-methylpiperidin-1-yl)methyl)-4'-(trifluoromethyl)biphenyl-3-yl)propanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: 17 h / -78 - 20 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h

3.1: 4-methyl-1,2,3-trifluorobenzene / 1 h / 120 °C / Microwave irradiation; Inert atmosphere

4.1: pyridine / dichloromethane / 2 h / 20 °C / Inert atmosphere

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; water; toluene / 4 h / 80 °C / Inert atmosphere

6.1: water; sodium hydroxide / tetrahydrofuran; methanol / 0.17 h / 100 °C / Microwave irradiation; Inert atmosphere

7.1: carbon dioxide / methanol; isopropyl alcohol / 75007.5 Torr / Resolution of racemate; Inert atmosphere

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; carbon dioxide; palladium 10% on activated carbon; water; hydrogen; sodium carbonate; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; isopropyl alcohol; toluene; 4-methyl-1,2,3-trifluorobenzene; 3.1: Mannich reaction / 5.1: Suzuki coupling;
DOI:10.1021/ml200175q