2-(6-((4-fluorophenyl)(4-methylpiperidin-1-yl)methyl)-4'-(trifluoromethyl)biphenyl-3-yl)propanoic acid

Base Information

Chemical Name:2-(6-((4-fluorophenyl)(4-methylpiperidin-1-yl)methyl)-4'-(trifluoromethyl)biphenyl-3-yl)propanoic acid
CAS No.:1257395-14-4
Molecular Formula:C₂₉H₂₉F₄NO₂
Molecular Weight:499.548
Hs Code.:

Synonyms:2-(6-((4-fluorophenyl)(4-methylpiperidin-1-yl)methyl)-4'-(trifluoromethyl)biphenyl-3-yl)propanoic acid

Suppliers and Price of 2-(6-((4-fluorophenyl)(4-methylpiperidin-1-yl)methyl)-4'-(trifluoromethyl)biphenyl-3-yl)propanoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(6-((4-fluorophenyl)(4-methylpiperidin-1-yl)methyl)-4'-(trifluoromethyl)biphenyl-3-yl)propanoic acid

Chemical Property:

Purity/Quality:: 95% ^*data from raw suppliers

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Technology Process of 2-(6-((4-fluorophenyl)(4-methylpiperidin-1-yl)methyl)-4'-(trifluoromethyl)biphenyl-3-yl)propanoic acid

There total 9 articles about 2-(6-((4-fluorophenyl)(4-methylpiperidin-1-yl)methyl)-4'-(trifluoromethyl)biphenyl-3-yl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1257398-00-7
methyl 2-(6-((4-fluorophenyl)(4-methylpiperidin-1-yl)methyl)-4'-(trifluoromethyl)biphenyl-3-yl)propanoate

: 1257395-14-4
2-(6-((4-fluorophenyl)(4-methylpiperidin-1-yl)methyl)-4'-(trifluoromethyl)biphenyl-3-yl)propanoic acid

Guidance literature:: With water; sodium hydroxide; In tetrahydrofuran; methanol; at 100 ℃; for 0.166667h; Microwave irradiation; Inert atmosphere;
DOI:10.1021/ml200175q

Reference yield:

: 42058-59-3
3-hydroxy-benzeneacetic acid, methyl ester

: 1257395-14-4
2-(6-((4-fluorophenyl)(4-methylpiperidin-1-yl)methyl)-4'-(trifluoromethyl)biphenyl-3-yl)propanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / acetonitrile / 6 h / 20 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: 17 h / -78 - 20 °C / Inert atmosphere

3.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h

4.1: 4-methyl-1,2,3-trifluorobenzene / 1 h / 120 °C / Microwave irradiation; Inert atmosphere

5.1: pyridine / dichloromethane / 2 h / 20 °C / Inert atmosphere

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; water; toluene / 4 h / 80 °C / Inert atmosphere

7.1: water; sodium hydroxide / tetrahydrofuran; methanol / 0.17 h / 100 °C / Microwave irradiation; Inert atmosphere

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; water; hydrogen; sodium carbonate; potassium carbonate; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; toluene; acetonitrile; 4-methyl-1,2,3-trifluorobenzene; 4.1: Mannich reaction / 6.1: Suzuki coupling;
DOI:10.1021/ml200175q

Reference yield:

: 62969-42-0
3-benzyloxy-phenylacetic acid methyl ester

: 1257395-14-4
2-(6-((4-fluorophenyl)(4-methylpiperidin-1-yl)methyl)-4'-(trifluoromethyl)biphenyl-3-yl)propanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: 17 h / -78 - 20 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h

3.1: 4-methyl-1,2,3-trifluorobenzene / 1 h / 120 °C / Microwave irradiation; Inert atmosphere

4.1: pyridine / dichloromethane / 2 h / 20 °C / Inert atmosphere

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; water; toluene / 4 h / 80 °C / Inert atmosphere

6.1: water; sodium hydroxide / tetrahydrofuran; methanol / 0.17 h / 100 °C / Microwave irradiation; Inert atmosphere

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; water; hydrogen; sodium carbonate; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; toluene; 4-methyl-1,2,3-trifluorobenzene; 3.1: Mannich reaction / 5.1: Suzuki coupling;
DOI:10.1021/ml200175q