3-<(benzyloxy)methoxymethyl>-1-cyclohexenecarbaldehyde

Base Information

• Chemical Name: 3-<(benzyloxy)methoxymethyl>-1-cyclohexenecarbaldehyde
• CAS No.: 97997-06-3
• Molecular Formula: C₁₆H₂₀O₃
• Molecular Weight: 260.333
• Mol file: 97997-06-3.mol

Synonyms:3-<(benzyloxy)methoxymethyl>-1-cyclohexenecarbaldehyde

Chemical Property of 3-<(benzyloxy)methoxymethyl>-1-cyclohexenecarbaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3-<(benzyloxy)methoxymethyl>-1-cyclohexenecarbaldehyde

There total 3 articles about 3-<(benzyloxy)methoxymethyl>-1-cyclohexenecarbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Benzyloxymethyl chloride (3587-60-8) → 3-<(benzyloxy)methoxymethyl>-1-cyclohexenecarbaldehyde (97997-06-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / diisopropylamine / dimethylformamide / 20 h / Ambient temperature

2: 1.) LDA, 2.) NaH, 3.) 5percent aq. HF

With hydrogen fluoride; sodium hydride; diisopropylamine; lithium diisopropyl amide; In N,N-dimethyl-formamide;

DOI:10.1021/jo00221a015

Reference yield:

2-(tert-butyldimethylsiloxy)-3-(hydroxymethyl)cyclohexanone → 3-<(benzyloxy)methoxymethyl>-1-cyclohexenecarbaldehyde (97997-06-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / diisopropylamine / dimethylformamide / 20 h / Ambient temperature

2: 1.) LDA, 2.) NaH, 3.) 5percent aq. HF

With hydrogen fluoride; sodium hydride; diisopropylamine; lithium diisopropyl amide; In N,N-dimethyl-formamide;

DOI:10.1021/jo00221a015

Reference yield:

(methoxymethyl)diphenylphosphine oxide (4455-77-0) + cis,trans-3-<(benzyloxy)methoxymethyl>-2-(tert-butyldimethylsiloxy)cyclohexanone → 3-<(benzyloxy)methoxymethyl>-1-cyclohexenecarbaldehyde (97997-06-3)

Guidance literature:

With hydrogen fluoride; sodium hydride; lithium diisopropyl amide; Yield given. Multistep reaction;

DOI:10.1021/jo00221a015

upstream raw materials:

(methoxymethyl)diphenylphosphine oxide

Benzyloxymethyl chloride

Downstream raw materials:

(E)-1-(3-Benzyloxymethoxymethyl-cyclohex-1-enyl)-3-trimethylsilanyl-prop-2-en-1-ol