(S)-methyl 2-((tert-butoxycarbonyl)amino)-2-(4,4-difluorocyclohexyl)acetate

Base Information

Chemical Name:(S)-methyl 2-((tert-butoxycarbonyl)amino)-2-(4,4-difluorocyclohexyl)acetate
CAS No.:394735-63-8
Molecular Formula:C₁₄H₂₃F₂NO₄
Molecular Weight:307.338
Hs Code.:

Synonyms:(S)-methyl 2-((tert-butoxycarbonyl)amino)-2-(4,4-difluorocyclohexyl)acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-methyl 2-((tert-butoxycarbonyl)amino)-2-(4,4-difluorocyclohexyl)acetate

Chemical Property:

Purity/Quality:

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Technology Process of (S)-methyl 2-((tert-butoxycarbonyl)amino)-2-(4,4-difluorocyclohexyl)acetate

There total 4 articles about (S)-methyl 2-((tert-butoxycarbonyl)amino)-2-(4,4-difluorocyclohexyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 848498-04-4
(S)-methyl 2-((tert-butoxycarbonyl)amino)-2-(4-oxocyclohexyl)acetate

: 394735-63-8,2270904-94-2
(S)-methyl 2-((tert-butoxycarbonyl)amino)-2-(4,4-difluorocyclohexyl)acetate

Guidance literature:: With (bis-(2-methoxyethyl)amino)sulfur trufluoride; In tetrahydrofuran; dichloromethane; at 0 - 20 ℃;

Reference yield:

: 676596-50-2
(S)-methyl 2-((tert-butoxycarbonyl)amino)-2-(4-hydroxycyclohexyl)acetate

: 394735-63-8,2270904-94-2
(S)-methyl 2-((tert-butoxycarbonyl)amino)-2-(4,4-difluorocyclohexyl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: Dess-Martin periodane / dichloromethane / 20 °C

2: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane; tetrahydrofuran / 0 - 20 °C

With Dess-Martin periodane; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In tetrahydrofuran; dichloromethane;

Reference yield:

: 225517-15-7
(S)-N^α-(tert-butyloxycarbonyl)-4-hydroxyphenylglycine methyl ester

: 394735-63-8,2270904-94-2
(S)-methyl 2-((tert-butoxycarbonyl)amino)-2-(4,4-difluorocyclohexyl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: platinum(IV) oxide; acetic acid; hydrogen / 96 h / 30 °C / 2482.38 Torr

2: Dess-Martin periodane / dichloromethane / 12 h / 0 - 10 °C

3: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane / 12 h / 0 - 10 °C

With platinum(IV) oxide; hydrogen; Dess-Martin periodane; acetic acid; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In dichloromethane;