a-(Boc-amino)-4,4-difluorocyclohexaneacetic acid

Base Information

• Chemical Name: a-(Boc-amino)-4,4-difluorocyclohexaneacetic acid
• CAS No.: 1822546-08-6
• Molecular Formula: C₁₃H₂₁F₂NO₄
• Molecular Weight: 293.311
• Mol file: 1822546-08-6.mol

Synonyms:

Chemical Property of a-(Boc-amino)-4,4-difluorocyclohexaneacetic acid

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

2-((tert-Butoxycarbonyl)amino)-2-(4,4-difluorocyclohexyl)acetic acid 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of a-(Boc-amino)-4,4-difluorocyclohexaneacetic acid

There total 10 articles about a-(Boc-amino)-4,4-difluorocyclohexaneacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

tert-butyl 2,5-dioxopyrrolidin-1-yl carbonate (13139-12-3) + (2S)-2-amino-2-(4,4-difluorocyclohexyl)acetic acid hydrochloride → (S)-2-((tert-butoxycarbonyl)amino)-2-(4,4-difluorocyclohexyl)acetic acid (1822546-08-6)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 24h;

Reference yield: 76.0%

di-tert-butyl dicarbonate (24424-99-5) + nickel(II) (2S)-2-[(E)-[[2-[(2S)-1-benzylpyrrolidine-2-carbonyl]azanidylphenyl]-phenyl-methylene]amino]-2-(4,4-difluorocyclohexyl)acetate → (S)-2-((tert-butoxycarbonyl)amino)-2-(4,4-difluorocyclohexyl)acetic acid (1822546-08-6)

Guidance literature:

nickel(II) (2S)-2-[(E)-[[2-[(2S)-1-benzylpyrrolidine-2-carbonyl]azanidylphenyl]-phenyl-methylene]amino]-2-(4,4-difluorocyclohexyl)acetate; With hydrogenchloride; water; In methanol; at 60 ℃; for 1h;

di-tert-butyl dicarbonate; With sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield:

4,4-difluorocyclohexane carboxyaldehyde (265108-36-9) → (S)-2-((tert-butoxycarbonyl)amino)-2-(4,4-difluorocyclohexyl)acetic acid (1822546-08-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: pyridinium p-toluenesulfonate; copper(II) sulfate / dichloromethane / 48 h / 20 °C

2.1: scandium tris(trifluoromethanesulfonate) / dichloromethane / 72 h / 20 °C

3.1: hydrogenchloride / water / 24 h / 80 °C

3.2: 45 h / 20 °C

With hydrogenchloride; pyridinium p-toluenesulfonate; copper(II) sulfate; scandium tris(trifluoromethanesulfonate); In dichloromethane; water;

upstream raw materials:

di-tert-butyl dicarbonate

tert-butyl 2,5-dioxopyrrolidin-1-yl carbonate

4,4-difluorocyclohexane carboxyaldehyde

(S)-methyl 2-((tert-butoxycarbonyl)amino)-2-(4-oxocyclohexyl)acetate